Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex.
Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex.
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DOI:
10.1016/j.neuron.2010.04.012
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发表时间:
2010-05-27
期刊:
影响因子:
16.2
通讯作者:
Bear, Mark F.
中科院分区:
文献类型:
--
作者:
Khibnik, Lena A.;Cho, Kathleen K. A.;Bear, Mark F.
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feed-forward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission.
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影响因子:
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