Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex.

Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex.
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DOI:
10.1016/j.neuron.2010.04.012
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发表时间:
2010-05-27
期刊:
影响因子:
16.2
通讯作者:
Bear, Mark F.
Bear, Mark F.
中科院分区:
医学1区
文献类型:
--
作者:
Khibnik, Lena A.;Cho, Kathleen K. A.;Bear, Mark F.

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短暂的单眼剥夺(MD)通过引起对被剥夺眼的反应抑制而改变初级视皮层的眼优势(OD)。在这里,我们解决在何种程度上的转变是由兴奋性突触传递的修改表示。MD 3天首先诱导OD偏移,然后皮质内多突触抑制性和兴奋性突触的影响被完全去除,只留下“前馈”丘脑皮质突触电流。结果表明,MD后OD值的快速漂移在丘脑皮层突触传递水平上有强烈的表达。
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feed-forward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission.
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