Long-term functional recovery and compensation after cerebral ischemia in rats.
Long-term functional recovery and compensation after cerebral ischemia in rats.
复制标题
DOI：
10.1016/j.bbr.2014.05.008
复制
发表时间：
2014-08-15
影响因子：
2.7
通讯作者：
Allan, Stuart M.
中科院分区：
文献类型：
--
作者：
Girard, Sylvie;Murray, Katie N.;Rothwell, Nancy J.;Metz, Gerlinde A. S.;Allan, Stuart M.
熟练的达成任务允许区分补偿和恢复。脑容量与长期运动功能相关，而与社会行为无关。急性IL-1 Ra导致恢复，而在媒介物处理的动物中观察到补偿。脑缺血是成人残疾的最常见原因之一，并导致长期运动和认知障碍，治疗可能性有限。治疗方案已被证明在脑缺血的临床前模型中有效，但在临床环境中失败。这种有限的翻译可能是由于所使用的模型和测量的结果的适用性，因为大多数研究都集中在损伤后的早期阶段与粗大运动量表，这与临床情况的相关性有限。本研究的目的是确定大鼠脑缺血后的长期功能结果，重点是精细运动功能，社会和抑郁行为作为临床相关措施。次要目的是评价抗炎治疗（白细胞介素-1受体拮抗剂（IL-1 Ra））对功能恢复和代偿的影响。脑容量与精细运动技能的长期（25天）损伤相关，但与行为的情感成分无关。运动障碍无法检测使用传统的神经系统测试和详细的分析允许恢复和补偿之间的区别。IL-1 Ra的急性全身给药（再灌注时）导致更快，更完全的恢复，但延迟（24小时）IL-1 Ra治疗没有效果。总之，脑损伤后的功能评估需要详细的运动测试，以解决由完整组织介导的长期损伤和补偿过程。脑损伤后熟练运动的功能缺陷是长期预后的理想预测指标，应成为临床前动物模型评估的标准指标。
Skilled reaching task allowed to differentiate between compensation and recovery. Infarct size correlated with long-term motor function, not with social behavior. Acute IL-1Ra led to recovery while compensation is seen in vehicle-treated animals. Cerebral ischemia is one of the most common causes of disabilities in adults and leads to long-term motor and cognitive impairments with limited therapeutic possibilities. Treatment options have proven efficient in preclinical models of cerebral ischemia but have failed in the clinical setting. This limited translation may be due to the suitability of models used and outcomes measured as most studies have focused on the early period after injury with gross motor scales, which have limited correlation to the clinical situation. The aim of this study was to determine long-term functional outcomes after cerebral ischemia in rats, focusing on fine motor function, social and depressive behavior as clinically relevant measures. A secondary objective was to evaluate the effects of an anti-inflammatory treatment (interleukin-1 receptor antagonist (IL-1Ra)) on functional recovery and compensation. Infarct volume was correlated with long-term (25 days) impairments in fine motor skills, but not with emotional components of behavior. Motor impairments could not be detected using conventional neurological tests and only detailed analysis allowed differentiation between recovery and compensation. Acute systemic administration of IL-1Ra (at reperfusion) led to a faster and more complete recovery, but delayed (24 h) IL-1Ra treatment had no effect. In summary functional assessment after brain injury requires detailed motor tests in order to address long-term impairments and compensation processes that are mediated by intact tissues. Functional deficits in skilled movement after brain injury represent ideal predictors of long-term outcomes and should become standard measures in the assessment of preclinical animal models.
登录
查看更多内容
影响因子：
5.3
作者：
Audet MC;Anisman H
通讯作者：
Anisman H
影响因子：
5.3
作者：
Ji, Shengbo;Kronenberg, Golo;Endres, Matthias
通讯作者：
Endres, Matthias
影响因子：
3
作者：
Metz, GA;Whishaw, IQ
通讯作者：
Whishaw, IQ
影响因子：
11
作者：
Goshen, I.;Kreisel, T.;Yirmiya, R.
通讯作者：
Yirmiya, R.
影响因子：
3
作者：
Balkaya, Mustafa;Kroeber, Jan;Endres, Matthias
通讯作者：
Endres, Matthias