Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses.
Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses.
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DOI：
10.3389/fncel.2013.00068
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发表时间：
2013
影响因子：
5.3
通讯作者：
Anisman H
中科院分区：
文献类型：
--
作者：
Audet MC;Anisman H
抑郁症的发展长期以来一直归因于单胺的变化，药物治疗策略同样集中在改变单胺可用性的方法上。然而，改变这些过程的治疗所取得的有限成功促使人们寻找替代机制和治疗方法。在这里，我们提供了一个简短的概述有关促炎细胞因子和生长因子在抑郁症中的可能作用，以及针对这些因素在治疗这种疾病的可能性。这些数据表明，专注于一种或另一种细胞因子或生长因子可能会适得其反，特别是因为这些因素可能会顺序或平行地影响抑郁症。这也表明，细胞因子和生长因子可能是有用的生物标志物，为抑郁症的个体化治疗。
The development of depressive disorders had long been attributed to monoamine variations, and pharmacological treatment strategies likewise focused on methods of altering monoamine availability. However, the limited success achieved by treatments that altered these processes spurred the search for alternative mechanisms and treatments. Here we provide a brief overview concerning a possible role for pro-inflammatory cytokines and growth factors in major depression, as well as the possibility of targeting these factors in treating this disorder. The data suggest that focusing on one or another cytokine or growth factor might be counterproductive, especially as these factors may act sequentially or in parallel in affecting depressive disorders. It is also suggested that cytokines and growth factors might be useful biomarkers for individualized treatments of depressive illnesses.
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影响因子：
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