The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats.
The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats.
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作者：
Chen JH;Song J;Chen Y;Ding Q;Peng A;Mao L
素食蛋白饮食在预防代谢综合征(METS)方面引起了越来越多的关注。同时，脂联素已成为预防甲硫氨酸代谢综合征的一个极具潜力的分子靶点。我们的研究将确定一种潜在的素食蛋白饮食，用于预防METS的大鼠模型。36只Wistar大鼠随机分为3组，分别饲喂含有酪蛋白(CAS)、大豆蛋白(Soy)和谷蛋白-大豆混合蛋白(GSM)的饲料，为期12周。检测代谢参数的变化以及脂联素及其受体的表达。与CAS饮食相比，大豆和GSM饮食均导致血总胆固醇和甘油三酯降低，但仅GSM饮食导致高密度脂蛋白-胆固醇升高；三组血糖均无显著差异；HOMA-IR仅豆制品组较低。各组间血清脂联素水平排序为GSM>；Soy>；CAS。脂肪组织中脂联素的表达和骨骼肌中AdipoR1mRNA的表达也有相似的顺序。我们的结果首次表明，除大豆饮食外，GSM饮食也可能作为动物蛋白的替代品来预防METS。
Vegan protein-based diet has attracted increasing interest in the prevention of metabolic syndrome (MetS). Meanwhile, adiponectin has become a highly potential molecular target in the prevention of MetS. Our study will identify a potential vegan protein diet for the prevention of MetS using rat models. Thirty-six Wistar rats were randomly assigned into three groups and given diets containing one of the following proteins for 12 weeks: casein (CAS, control diet), soy protein (SOY), and gluten-soy mixed protein (GSM). Changes in metabolic parameters as well as the expressions of adiponectin and its receptors were identified. Compared to CAS diet, both SOY and GSM diets led to decreases in blood total cholesterol and triglycerides, but only GSM diet led to an increase in HDL-cholesterol; no marked difference was observed in blood glucose in all three groups; HOMA-IR was found lower only in SOY group. Among groups, the order of serum adiponectin level was found as GSM > SOY > CAS. Similar order pattern was also observed in expression of adiponectin in adipose tissue and AdipoR1 mRNA in skeletal muscle. Our results suggested for the first time that, besides SOY diet, GSM diet could also be a possible substitute of animal protein to prevent MetS.
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大豆蛋白和异黄酮对雄性猴子胰岛素抵抗和脂联素的影响。
影响因子：
9.8
作者：
Wagner, Janice D.;Zhang, Li;Shadoan, Melanie K.;Kavanagh, Kylie;Chen, Haiying;Tresnasari, Kristianti;Kaplan, Jay R.;Adams, Michael R.
通讯作者：
Adams, Michael R.
影响因子：
158.5
作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
通讯作者：
COOKNEWELL, ME
大鼠骨骼肌中脂联素受体adipor1的过表达会扩增局部胰岛素敏感性。
影响因子：
4.8
作者：
Patel SA;Hoehn KL;Lawrence RT;Sawbridge L;Talbot NA;Tomsig JL;Turner N;Cooney GJ;Whitehead JP;Kraegen EW;Cleasby ME
通讯作者：
Cleasby ME
DOI：
10.2147/dmso.s19635
发表时间：
2011
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Sasakabe T;Haimoto H;Umegaki H;Wakai K
通讯作者：
Wakai K
影响因子：
4.4
作者：
Brandsch, Corinna;Shukla, Anjali;Eder, Klaus
通讯作者：
Eder, Klaus