Attenuation measuring ultrasound shearwave elastography and in vivo application in post-transplant liver patients.
Attenuation measuring ultrasound shearwave elastography and in vivo application in post-transplant liver patients.
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超声剪切波弹性成像的衰减测量及其在肝移植后患者体内的应用。
DOI：
10.1088/1361-6560/aa4f6f
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发表时间：
2017-01-21
影响因子：
3.5
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Nenadic IZ;Qiang B;Urban MW;Zhao H;Sanchez W;Greenleaf JF;Chen S
超声和磁共振弹性成像技术用于评估软组织的机械性能。组织硬度与各种病理学有关，例如纤维化、顺应性丧失和癌症。执行弹性成像的一种方式是测量由固有运动或外部振动源引起的组织中的传播波的剪切波速度，并将剪切波速度与组织弹性相关联。所有组织都是固有粘弹性的，忽略粘度会使基于速度的弹性估计产生偏差，并忽略组织健康的潜在重要参数。我们提出了衰减测量超声剪切波弹性成像（AMUSE），一种技术，独立测量剪切波的速度和组织中的衰减，因此允许粘弹性的表征，而不使用流变模型。AMUSE的理论基础是第一次推导和验证有限元模拟。AMUSE针对用于评估组织模拟体模和切除组织中剪切波速度（相位梯度）和衰减（振幅衰减）的传统方法进行了验证。结果在一个标准差内一致。AMUSE被用来测量剪切波速度和衰减在15个潜在的急性排斥反应患者的移植肝，并在初步研究中与活检结果进行了比较。比较显示出极好的一致性，并表明AMUSE可用于分离具有急性排斥反应的移植肝与无排斥反应的肝。
Ultrasound and magnetic resonance elastography techniques are used to assess mechanical properties of soft tissues. Tissue stiffness is related to various pathologies such as fibrosis, loss of compliance, and cancer. One way to perform elastography is measuring shear wave velocity of propagating waves in tissue induced by intrinsic motion or an external source of vibration, and relating the shear wave velocity to tissue elasticity. All tissues are inherently viscoelastic and ignoring viscosity biases the velocity-based estimates of elasticity and ignores a potentially important parameter of tissue health. We present Attenuation Measuring Ultrasound Shearwave Elastography (AMUSE), a technique that independently measures both shear wave velocity and attenuation in tissue and therefore allows characterization of viscoelasticity without using a rheological model. The theoretical basis for AMUSE is first derived and validated in finite element simulations. AMUSE is validated against the traditional methods for assessing shear wave velocity (phase gradient) and attenuation (amplitude decay) in tissue mimicking phantoms and excised tissue. The results agreed within one standard deviation. AMUSE was used to measure shear wave velocity and attenuation in 15 transplanted livers in patients with potential acute rejection, and the results were compared with the biopsy findings in a preliminary study. The comparison showed excellent agreement and suggests that AMUSE can be used to separate transplanted livers with acute rejection from livers with no rejection.
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影响因子：
2.4
作者：
Bernal, Miguel;Nenadic, Ivan;Greenleaf, James F.
通讯作者：
Greenleaf, James F.
DOI：
10.1109/tuffc.2009.1067
发表时间：
2009-03-01
影响因子：
3.6
作者：
Montaldo, Gabriel;Tanter, Mickael;Fink, Mathias
通讯作者：
Fink, Mathias
DOI：
10.1109/tuffc.2014.2990
发表时间：
2014-06-01
影响因子：
3.6
作者：
Gennisson, Jean-Luc;Marcellan, Alba;Tanter, Mickael
通讯作者：
Tanter, Mickael
DOI：
10.1109/tuffc.2007.273
发表时间：
2007-03-01
影响因子：
3.6
作者：
Fromageau, Jeremie;Gennisson, Jean-Luc;Cloutier, Guy
通讯作者：
Cloutier, Guy
影响因子：
19.7
作者：
Chen, Shigao;Sanchez, William;Metz, Stephen
通讯作者：
Metz, Stephen