Chronotype and breast cancer risk in a cohort of US nurses.
Chronotype and breast cancer risk in a cohort of US nurses.
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DOI：
10.3109/07420528.2013.809359
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发表时间：
2013-11
影响因子：
2.8
通讯作者：
Schernhammer ES
中科院分区：
文献类型：
--
作者：
Ramin C;Devore EE;Pierre-Paul J;Duffy JF;Hankinson SE;Schernhammer ES
这项研究的目的是检查时型和乳腺癌风险之间的关系。我们分析了护士健康研究II(NHS II)中72 517名女性的时间类型(确定的晨型、可能的晨型、可能的晚型、确定的晚型、或既不是早型也不是晚型)与乳腺癌风险的关系。2009年自行报告了时型，在1989-2007年间，参与者中确认了1834例乳腺癌病例；施加了2年的滞后期，以说明与乳腺癌诊断相关的可能的昼夜节律中断。年龄和多变量调整后的Logistic回归用于估计优势比(OR)和95%可信区间(CI)。与明确的早起型相比，自我报告既不是早起型也不是晚起型的参与者患乳腺癌的风险增加27%(多变量调整后的OR=1.27；95%CI，1.04-1.56)。其他时型与乳腺癌风险无显著相关性(多变量调整后OR=0.99，95%CI，0.87~1.12，OR=0.96，95%CI，0.84~1.09，OR=1.15，95%CI，0.98~1.34，OR=1.15，95%CI，0.98~1.34)。总体而言，在我们的研究中，时型与乳腺癌风险无关。早晚时型之间风险的适度增加可能表明昼夜节律紊乱是一种潜在的潜在机制；然而，需要更多的研究来证实我们的结果。
The aim of this study was to examine the relation between chronotype and breast cancer risk. We analyzed the association between chronotype (definite morning type, probable morning type, probable evening type, definite evening type, or neither morning nor evening type) and breast cancer risk among 72 517 women in the Nurses’ Health Study II (NHS II). Chronotype was self-reported in 2009, and 1834 breast cancer cases were confirmed among participants between 1989–2007; a 2-year lag period was imposed to account for possible circadian disruptions related to breast cancer diagnosis. Age- and multivariable-adjusted logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Participants who self-reported as neither morning nor evening chronotype had a 27% increased risk of breast cancer (multivariable-adjusted OR= 1.27; 95% CI, 1.04–1.56), compared to definite morning types. None of the other chronotypes were significantly associated with breast cancer risk (multivariable-adjusted OR= .99, 95% CI, .87–1.12 for probable morning vs. definite morning types, OR=.96, 95% CI, .84–1.09 for probable evening vs. definite morning types, and OR=1.15, 95% CI, .98–1.34 for definite evening vs. definite morning types). Overall, chronotype was not associated with breast cancer risk in our study. A modestly increased risk among neither morning nor evening chronotypes may indicate circadian disruption as a potentially underlying mechanism; however, more studies are needed to confirm our results.
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影响因子：
3.7
作者：
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影响因子：
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