Nightshift work and risk of ovarian cancer.
Nightshift work and risk of ovarian cancer.
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DOI：
10.1136/oemed-2012-101146
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发表时间：
2013-04
影响因子：
4.9
通讯作者：
Rossing MA
中科院分区：
文献类型：
--
作者：
Bhatti P;Cushing-Haugen KL;Wicklund KG;Doherty JA;Rossing MA
动物证据表明，昼夜节律紊乱可能与卵巢癌有关，尽管很少有流行病学工作来评估这种潜在的联系。我们在一项基于人群的病例对照研究中评估了自我报告的夜班工作（一种已知的昼夜节律干扰物）与卵巢癌之间的关联。这项研究包括1,101名患有浸润性上皮性卵巢癌的妇女，389名患有交界性上皮性卵巢肿瘤的妇女和1,832名对照，并在西华盛顿州进行。轮班工作数据收集的一部分，在人的采访。夜班工作与侵袭性疾病的风险增加有关。（OR=1.24，95%CI：1.04-1.49）和交界性（OR=1.48，95%CI：1.15-1.90）肿瘤;然而，我们几乎没有观察到风险随着夜班工作累积时间的增加而增加的证据，并且风险在最高持续时间类别（>7夜班工作年）中没有升高。增加的风险仅限于50岁及以上的女性，以及浸润性和交界性肿瘤的浆液性和粘液性组织学。有证据表明，在报告偏好晚上而不是早上活动的女性中，卵巢癌的风险降低。我们发现有证据表明轮班工作与卵巢癌之间存在关联。在未来的研究中，除了关于轮班时间表的详细数据外，还应对这一观察结果进行随访，并对昼夜偏好（即时间型）进行详细评估。
Animal evidence suggests that circadian disruption may be associated with ovarian cancer, though very little epidemiologic work has been done to assess this potential association. We evaluated the association between self-reported nightshift work, a known circadian disruptor, and ovarian cancer in a population-based case-control study. The study included 1,101 women with invasive epithelial ovarian cancer, 389 women with borderline epithelial ovarian tumors and 1,832 controls and was conducted in Western Washington State. Shift work data was collected as part of in-person interviews. Working the nightshift was associated with an increased risk of invasive (OR=1.24, 95% CI: 1.04–1.49) and borderline (OR=1.48, 95% CI: 1.15–1.90) tumors; however, we observed little evidence that risks increased with increasing cumulative duration of nightshift work, and risks were not elevated in the highest duration category (>7 nightshift work-years). Increased risks were restricted to women who were 50 years of age and older and to serous and mucinous histologies of invasive and borderline tumors. There was suggestive evidence of a decreased risk of ovarian cancer among women reporting a preference for activity during evenings rather than mornings. We found evidence suggesting an association between shift work and ovarian cancer. This observation should be followed up in future studies incorporating detailed assessments of diurnal preference (i.e. chronotype) in addition to detailed data on shift schedules.
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日晒和上皮卵巢癌的风险。
影响因子：
2.3
作者：
Bodelon, Clara;Cushing-Haugen, Kara L.;Wicklund, Kristine G.;Doherty, Jennifer A.;Rossing, Mary Anne
通讯作者：
Rossing, Mary Anne
影响因子：
4.7
作者：
Kurian, AW;Balise, RR;Whittemore, AS
通讯作者：
Whittemore, AS
影响因子：
10.3
作者：
Schernhammer, ES;Laden, F;Colditz, GA
通讯作者：
Colditz, GA
DOI：
10.1158/1055-9965.epi-11-0138
发表时间：
2011-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Poole EM;Schernhammer ES;Tworoger SS
通讯作者：
Tworoger SS
影响因子：
51.1
作者：
Straif, Kurt;Baan, Robert;Cogliano, Vincent
通讯作者：
Cogliano, Vincent