Obesity and cognitive decline: role of inflammation and vascular changes.

Obesity and cognitive decline: role of inflammation and vascular changes.
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DOI:
10.3389/fnins.2014.00375
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发表时间:
2014
影响因子:
4.3
通讯作者:
Jenkins TA
Jenkins TA
中科院分区:
医学2区
文献类型:
--
作者:
Nguyen JC;Killcross AS;Jenkins TA

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中年肥胖症的发病率明显增加,与此同时,包括心血管疾病和II型糖尿病在内的代谢紊乱的发病率也在上升。许多研究表明,肥胖和代谢紊乱都与认知能力低下、认知能力下降和痴呆有关。在这篇综述中,我们讨论了肥胖对认知能力的影响,包括临床和临床前观察,并讨论了一些潜在的机制,即炎症和血管和代谢改变。
The incidence of obesity in middle age is increasing markedly, and in parallel the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia. In this review we discuss the effects of obesity on cognitive performance, including both clinical and preclinical observations, and discuss some of the potential mechanisms involved, namely inflammation and vascular and metabolic alterations.
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