Obesity and cognitive decline: role of inflammation and vascular changes.
Obesity and cognitive decline: role of inflammation and vascular changes.
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DOI:
10.3389/fnins.2014.00375
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发表时间:
2014
影响因子:
4.3
通讯作者:
Jenkins TA
中科院分区:
文献类型:
--
作者:
Nguyen JC;Killcross AS;Jenkins TA
The incidence of obesity in middle age is increasing markedly, and in parallel the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia. In this review we discuss the effects of obesity on cognitive performance, including both clinical and preclinical observations, and discuss some of the potential mechanisms involved, namely inflammation and vascular and metabolic alterations.
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