The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats.
The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats.
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DOI：
10.1016/j.physbeh.2012.05.015
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发表时间：
2012-08-20
影响因子：
2.9
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Davidson TL;Monnot A;Neal AU;Martin AA;Horton JJ;Zheng W
食用高能（HE）饮食（即高饱和脂肪和糖的饮食）的大鼠表现出海马依赖的学习和记忆受损（例如，）。为了进一步研究这一效应，我们对限制低脂实验室食物的大鼠进行了训练，以解决海马依赖的系列特征阴性（FN）和海马独立的简单辨别问题。训练结束后，实验组接受实验室随意喂食。其余大鼠随意饲喂HE饮食。在HE饮食暴露7、14、21和28天后，分别测试了对这两个歧视问题的表现。FN，但不是简单的歧视，最初在所有大鼠中被废除，然后在Chow组中重新出现。对于喂食HE饮食的大鼠，那些体重最小、体脂量最低的大鼠（HE- dr大鼠）在这两个辨别问题上的表现与Chow组相似。然而，HE饮食诱导肥胖（HE- dio）大鼠（即体重最大、体脂最多的大鼠）在简单辨别问题上的表现与Chow组相似，但在FN问题上的整个测试过程中都受到损害。随后对血脑屏障（BBB）渗透性的评估显示，相对于HE-DR和Chow组，HE-DIO大鼠的海马体中外源性染料浓度升高，但纹状体和前额叶皮层中的浓度没有升高。结果表明，高糖饮食对海马依赖性认知功能的不良影响与对血脑屏障的有害影响有关，并且这两种结果都随高糖饮食引起的体重和肥胖增加的敏感性而变化。
Rats that consume high-energy (HE) diets (i.e., diets high in saturated fats and sugar) show impaired hippocampal-dependent learning and memory (e.g.,). To further investigate this effect, we trained rats given restricted access to low-fat lab chow on hippocampal-dependent serial feature-negative (FN) and hippocampal-independent simple discrimination problems. When training was completed, Group Chow received ad libitum lab chow. The remaining rats received ad libitum HE diet. Performance on both discrimination problems was tested following 7, 14, 21 and 28 days of HE diet exposure. FN, but not simple discrimination, was abolished initially for all rats, and then re-emerged for Group Chow. For rats fed HE diet, those that weighed the least and had lowest amount of body fat (HE-diet resistant (HE-DR) rats), performed like Group Chow on both discrimination problems. However, HE diet-induced obese (HE-DIO) rats (i.e., rats that weighed the most weight and had the most body fat) performed like Group Chow on the simple discrimination problem, but were impaired throughout testing on the FN problem. Subsequent assessment of blood-brain barrier (BBB) permeability revealed that concentrations of an exogenously administered dye were elevated in the hippocampus, but not in the striatum or prefrontal cortex for HE-DIO rats relative to the HE-DR and Chow groups. The results indicate that the adverse consequences of HE diet on hippocampal-dependent cognitive functioning are associated with detrimental effects on the BBB and that both of these outcomes vary with sensitivity to HE diet-induced increases in weight and adiposity.
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影响因子：
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