Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men.

Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men.
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DOI:
10.1002/ijc.24770
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发表时间:
2010-01-15
影响因子:
6.4
通讯作者:
Snijders, Peter J. F.
Snijders, Peter J. F.
中科院分区:
医学1区
文献类型:
--
作者:
Smith, Jennifer S.;Backes, Danielle M.;Hudgens, Michael G.;Bailey, Robert C.;Veronesi, Giovanni;Bogaarts, Martijn;Agot, Kawango;Ndinya-Achola, J. O.;Maclean, Ian;Agingu, Walter;Meijer, Chris J. L. M.;Moses, Stephen;Snijders, Peter J. F.

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在肯尼亚基苏穆的2,705名性活跃、未行包皮环切术、人类免疫缺陷病毒血清阴性的17-28岁男性中估计了人乳头瘤病毒(HPV)的患病率。阴茎头/冠状沟和/或阴茎干细胞中HPV的患病率为51.1%(95%置信区间:49.2 - 53.0%)。HPV感染率因解剖部位而异,龟头/冠状沟的阳性率为46.5%,而干部的阳性率为19.1%(p<0.0001)。在31.2%的龟头和12.3%的干细胞样本中检测到高危型HPV(p<0.0001)。HPV 16是最常见的类型,29.2%的男性感染了一种以上的HPV类型。HPV感染的危险因素包括C。trachomatis、N.淋病,自我报告的性传播感染,以及不经常洗澡。终生性伴侣数量和单纯疱疹病毒2型血清阳性也与HPV感染有轻微相关性。
Human papillomavirus (HPV) prevalence was estimated from 2,705 sexually active, uncircumcised, human immunodeficiency virus seronegative men aged 17–28 years in Kisumu, Kenya. HPV prevalence was 51.1% (95% confidence interval: 49.2 – 53.0%) in penile cells from the glans/coronal sulcus and/or shaft. HPV prevalence varied by anatomical site, with 46.5% positivity in the glans/coronal sulcus compared with 19.1% in the shaft (p<.0001). High-risk HPV was detected in 31.2% of glans and 12.3% of shaft samples (p<.0001). HPV16 was the most common type and 29.2% of men were infected with more than one HPV type. Risk factors for HPV infection included presence of C. trachomatis, N. gonorrhea, self-reported sexually transmitted infections, and less frequent bathing. Lifetime number of sexual partners and herpes simplex virus type-2 seropositivity were also marginally associated with HPV infection.
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