Antidepressant effects of resveratrol in an animal model of depression.
Antidepressant effects of resveratrol in an animal model of depression.
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DOI：
10.1016/j.bbr.2014.03.052
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发表时间：
2014-07-15
影响因子：
2.7
通讯作者：
Tizabi, Yousef
中科院分区：
文献类型：
--
作者：
Hurley, Laura L.;Akinfiresoye, Luli;Kalejaiye, Olubukola;Tizabi, Yousef
白藜芦醇（3，4 '，5-trihydroxy-trans-stilbene）是在葡萄酒加工过程中从红葡萄中提取的一种天然非黄酮类多酚类抗氧化剂。最初人们研究它作为抗癌药物的潜力，后来发现它可以减少心血管疾病。最近，白藜芦醇被证明可以减轻小鼠和大鼠因压力或其他方式引起的抑郁症状。本研究的主要目的是研究白藜芦醇是否会表现出抗抑郁作用的Wistar-Kyoto（WKY）大鼠，一个假定的和非诱导的抑郁症动物模型，以及这种效果是否可能与海马和额叶皮质脑源性神经营养因子（BDNF），一种蛋白质的增加，涉及许多抗抑郁药的慢性效应。将成年雄性WKY大鼠注射两种剂量的白藜芦醇（10和40 mg/kg，i. p.）并在单次急性注射后或每天治疗7天后评价它们在旷场运动活动（LMA）、强迫游泳试验（FST：无助的量度）和蔗糖偏好试验（SPT：快感缺乏的量度）中的行为。急性和慢性给药白藜芦醇导致FST的剂量依赖性降低。然而，只有慢性白藜芦醇导致蔗糖消耗量呈剂量依赖性增加。LMA不受任何治疗的影响。平行观察到的行为影响海马，但不是额叶皮质，BDNF的水平也呈剂量依赖性升高后，慢性白藜芦醇管理。这些研究结果表明，在抑郁症动物模型中，白藜芦醇可能通过激活海马BDNF发挥抗抑郁样作用，并提示白藜芦醇至少在抑郁症患者亚群中具有治疗潜力。
Resveratrol (3,4’,5-trihydroxy-trans-stilbene) is a natural non-flavonoid polyphenol antioxidant extracted from red grapes in the processing of wine. Initially it was studied for its potential as anticancer drug, and later was found to reduce cardiovascular disease. More recently resveratrol was shown to alleviate depressive-like symptoms induced by stress or other means in mice and rats. The major purpose of this study was to investigate whether resveratrol would manifest an antidepressant effect in Wistar-Kyoto (WKY) rats, a putative and non-induced animal model of depression, and whether this effect might be associated with an increase in hippocampal and frontal cortical brain-derived neurotrophic factor (BDNF), a protein implicated in chronic effects of many antidepressants. Adult male WKY rats were injected with two doses of resveratrol (10 and 40 mg/kg, i.p.) and their behavior in the open field locomotor activity (LMA), forced swim test (FST: a measure of helplessness), and sucrose preference test (SPT: a measure of anhedonia) was evaluated after a single acute injection or following 7 days of daily treatment. Both acute and chronic administration of resveratrol resulted in a dose-dependent decrease in FST. However, only chronic resveratrol resulted in dose-dependent increase in sucrose consumption. LMA was not affected by any treatment. Parallel to the observed behavioral effects the level of hippocampal, but not frontal cortical, BDNF was also dose-dependently elevated after chronic resveratrol administration. These findings indicate an antidepressant-like effect of resveratrol in an animal model of depression possibly via activation of hippocampal BDNF, and suggest therapeutic potential of resveratrol in at least a subpopulation of depressed patients.
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影响因子：
2.7
作者：
Hurley, Laura L.;Akinfiresoye, Luli;Nwulia, Evaristus;Kamiya, Atsushi;Kulkarni, Amol A.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
影响因子：
3.6
作者：
Getachew, Bruk;Hauser, Sheketha R.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
影响因子：
10.6
作者：
Duman, RS;Malberg, J;D'Sa, C
通讯作者：
D'Sa, C
影响因子：
3.6
作者：
Getachew, Bruk;Hauser, Sheketha R.;Taylor, Robert E.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
白藜芦醇可预防大鼠慢性不可预测的轻度应激引起的认知受损
DOI：
10.1016/j.pnpbp.2013.10.017
发表时间：
2014-03-03
影响因子：
5.6
作者：
Liu, Dexiang;Zhang, Qingrui;Wang, Zhen
通讯作者：
Wang, Zhen