GABAergic circuits reflect different requirements for emergent perception in postnatal mouse neocortex
GABAergic circuits reflect different requirements for emergent perception in postnatal mouse neocortex
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GABA能回路反映了出生后小鼠新皮质对紧急感知的不同要求
DOI：
10.1101/2023.11.21.568139
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ghezzi F
中科院分区：
文献类型：
--
作者：
Ghezzi F
哺乳动物大脑皮层的信息传递依赖于局部投射的GABA能神经元间回路，人们普遍认为这些回路在新皮质区域是一致的。我们证明，在主动感官探索开始之前，出生后生活的高度动态期并不是这样。在此期间，由神经肽生长抑素的表达所定义的中间神经元的子集在初级躯体感觉和视觉皮质的感觉诱发活动中起着不同的作用。这两个区域之间的功能差异可以通过生长抑素中间神经元亚型的组成以及这些细胞形成的瞬时回路的不同来解释；体感回路代表着控制早期新生儿触摸信息的适应。了解这种依赖于区域的差异将促进我们努力理解发育性精神障碍的病因学。摘要皮层回路适应发育中大脑的局部信息处理需求
Information transfer in the mammalian cerebral cortex is dependent on locally-projecting GABAergic interneuron circuits that are widely assumed to be uniform across neocortical areas. We demonstrate that this does not hold true during the highly dynamic period of postnatal life prior to the onset of active sensory exploration. During this time, a subset of interneuron defined by expression of the neuropeptide somatostatin differentially contribute to sensory-evoked activity in primary somatosensory and visual cortices. This functional divergence between the two areas is explained by differences in the composition of somatostatin interneuron subtypes and the transient circuits formed by these cells; the somatosensory circuit representing an adaptation to control early neonatal touch information. Understanding such area-dependent differences will promote our endeavours to understand the aetiology of developmental psychiatric disorders.Summary SentenceCortical circuits are adapted to the local information processing demands of the developing brain
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25
作者：
Chittajallu, Ramesh;Isaac, John T. R.
通讯作者：
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影响因子：
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