Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
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DOI：
10.1016/j.chom.2013.07.007
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发表时间：
2013-08-14
影响因子：
30.3
通讯作者：
Garrett WS
中科院分区：
文献类型：
--
作者：
Kostic AD;Chun E;Robertson L;Glickman JN;Gallini CA;Michaud M;Clancy TE;Chung DC;Lochhead P;Hold GL;El-Omar EM;Brenner D;Fuchs CS;Meyerson M;Garrett WS
越来越多的证据表明肠道微生物群与结直肠癌有关。宏基因组分析表明共生梭杆菌属。与人类结直肠癌有关，但这是否是间接或因果联系仍不清楚。我们发现梭杆菌属。相对于周围组织，在人类结肠腺瘤中以及与健康受试者相比，在结直肠腺瘤和癌症患者的粪便样本中富集。此外，在肠道肿瘤发生的 ApcMin/+ 小鼠模型中，具核梭杆菌增加了肿瘤的多样性，并选择性地招募肿瘤浸润的骨髓细胞，从而促进肿瘤的进展。暴露于具核梭杆菌的 ApcMin/+ 小鼠的肿瘤表现出与人类梭杆菌阳性结直肠癌共有的促炎表达特征。然而，与其他与结直肠癌相关的细菌不同，具核梭菌不会加剧结肠炎、肠炎或炎症相关的肠道癌变。总的来说，这些数据表明，通过招募肿瘤浸润免疫细胞、梭杆菌，产生有利于结直肠肿瘤进展的促炎微环境。
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that commensal Fusobacterium spp. are associated with human colorectal carcinoma but whether this is an indirect or causal link remains unclear. We find that Fusobacterium spp. are enriched in human colonic adenomas relative to surrounding tissues and in stool samples from colorectal adenoma and carcinoma patients compared to healthy subjects. Additionally, in the ApcMin/+ mouse model of intestinal tumorigenesis, Fusobacterium nucleatum increases tumor multiplicity and selectively recruits tumor-infiltrating myeloid cells, which can promote tumor progression. Tumors from ApcMin/+ mice exposed to F. nucleatum exhibit a pro-inflammatory expression signature that is shared with human fusobacteria-positive colorectal carcinomas. However, unlike other bacteria linked to colorectal carcinoma, F. nucleatum does not exacerbate colitis, enteritis or inflammation-associated intestinal carcinogenesis. Collectively, these data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria, generate a pro-inflammatory microenvironment that is conducive for colorectal neoplasia progression.
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影响因子：
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作者：
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通讯作者：
Pollard, Jeffrey W.
影响因子：
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Han, YW;Shi, WY;Genco, RJ
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影响因子：
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Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
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影响因子：
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作者：
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通讯作者：
Karin, Michael
影响因子：
64.8
作者：
Mellman, Ira;Coukos, George;Dranoff, Glenn
通讯作者：
Dranoff, Glenn