Biomechanics of meniscus cells: regional variation and comparison to articular chondrocytes and ligament cells.
Biomechanics of meniscus cells: regional variation and comparison to articular chondrocytes and ligament cells.
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DOI：
10.1007/s10237-012-0372-0
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发表时间：
2012-09
影响因子：
3.5
通讯作者：
Athanasiou, Kyriacos A.
中科院分区：
文献类型：
--
作者：
Sanchez-Adams, Johannah;Athanasiou, Kyriacos A.
理解膝关节半月板中的机械传导的中心是半月板细胞力学的表征。除了生物化学和几何学差异之外，半月板的内部和外部区域包含在形态和表型上不同的细胞。本研究与关节软骨细胞和韧带细胞相比，研究了半月板细胞力学的区域变化。结果发现，半月板包含两个生物力学上不同的细胞群，外侧半月板细胞比内侧半月板细胞更硬（1.59 ± 0.19 kPa）（1.07 ± 0.14 kPa）。此外，发现外半月板细胞和内半月板细胞的刚度与韧带细胞相似（1.32 ± 0.20 kPa），关节软骨细胞显示出最高的刚度（2.51 ± 0.20 kPa）。细胞的压缩特性的比较显示关节软骨细胞和内侧半月板细胞之间的相似性，以及外侧半月板细胞和韧带细胞之间的相似性。这些结果表明，细胞的生物力学在膝关节半月板区域不同，半月板细胞的生物力学相似的韧带细胞。在这项研究中确定的肌肉骨骼细胞的机械性能可能是有用的数学模型的发展或在各种软组织中研究mechanotransduction的实验设计。
Central to understanding mechanotransduction in the knee meniscus is the characterization of meniscus cell mechanics. In addition to biochemical and geometric differences, the inner and outer regions of the meniscus contain cells that are distinct in morphology and phenotype. This study investigated the regional variation in meniscus cell mechanics in comparison to articular chondrocytes and ligament cells. It was found that the meniscus contains two biomechanically distinct cell populations, with outer meniscus cells being stiffer (1.59 ± 0.19 kPa) than inner meniscus cells (1.07 ± 0.14 kPa). Additionally, it was found that both outer and inner meniscus cell stiffnesses were similar to ligament cells (1.32 ± 0.20 kPa), and articular chondrocytes showed the highest stiffness overall (2.51 ± 0.20 kPa). Comparison of compressibility characteristics of the cells showed similarities between articular chondrocytes and inner meniscus cells, as well as between outer meniscus cells and ligament cells. These results show that cellular biomechanics vary regionally in the knee meniscus, and that meniscus cells are biomechanically similar to ligament cells. The mechanical properties of musculoskeletal cells determined in this study may be useful for the development of mathematical models or the design of experiments studying mechanotransduction in a variety of soft tissues.
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影响因子：
3.5
作者：
Cao, Li;Guilak, Farshid;Setton, Lori A.
通讯作者：
Setton, Lori A.
影响因子：
7
作者：
Leipzig, N. D.;Eleswarapu, S. V.;Athanasiou, K. A.
通讯作者：
Athanasiou, K. A.
影响因子：
2.4
作者：
Darling, Eric M.;Topel, Matthew;Guilak, Farshid
通讯作者：
Guilak, Farshid
影响因子：
7
作者：
Darling, E. M.;Zauscher, S.;Guilak, F.
通讯作者：
Guilak, F.
DOI：
10.1243/095441105x34329
发表时间：
2005-09-01
影响因子：
1.8
作者：
Sweigart, MA;Athanasiou, KA
通讯作者：
Athanasiou, KA