Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.
Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.
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DOI：
10.3389/fnins.2015.00225
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发表时间：
2015
影响因子：
4.3
通讯作者：
Kolaitis G
中科院分区：
文献类型：
--
作者：
Theoharides TC;Stewart JM;Hatziagelaki E;Kolaitis G
大脑“迷雾”是一系列症状，包括认知能力下降，无法集中注意力和多任务处理，以及短期和长期记忆丧失。脑“雾”的特征是患有自闭症谱系障碍(ASD)、乳糜泻、慢性疲劳综合征、纤维肌痛、肥大细胞增多症和体位性心动过速综合征(POTS)的患者，以及“轻微认知损害”(阿尔茨海默病(AD)的早期临床表现)和其他神经精神障碍的患者。大脑的“迷雾”可能是由于炎症分子，包括肥大细胞(MC)释放的脂肪细胞因子和组胺，进一步刺激小胶质细胞激活，引起局灶性脑炎。最近的综述描述了天然类黄酮用于治疗神经精神和神经退行性疾病的潜在用途。黄酮木犀草素具有许多有用的作用，包括：抗氧化、抗炎、抑制小胶质细胞、神经保护和增强记忆力。橄榄果提取物中的木犀草素脂质体制剂改善了患有自闭症儿童和肥大细胞增多症患者脑部“雾”的注意力。甲基化的木犀草素类似物具有更高的活性和更好的生物利用度，可以开发成治疗神经精神疾病和大脑“雾”的有效药物。
Brain “fog” is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain “fog” characterizes patients with autism spectrum disorders (ASDs), celiac disease, chronic fatigue syndrome, fibromyalgia, mastocytosis, and postural tachycardia syndrome (POTS), as well as “minimal cognitive impairment,” an early clinical presentation of Alzheimer's disease (AD), and other neuropsychiatric disorders. Brain “fog” may be due to inflammatory molecules, including adipocytokines and histamine released from mast cells (MCs) further stimulating microglia activation, and causing focal brain inflammation. Recent reviews have described the potential use of natural flavonoids for the treatment of neuropsychiatric and neurodegenerative diseases. The flavone luteolin has numerous useful actions that include: anti-oxidant, anti-inflammatory, microglia inhibition, neuroprotection, and memory increase. A liposomal luteolin formulation in olive fruit extract improved attention in children with ASDs and brain “fog” in mastocytosis patients. Methylated luteolin analogs with increased activity and better bioavailability could be developed into effective treatments for neuropsychiatric disorders and brain “fog.”
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