Plasma atrial natriuretic polypeptide as an index of left ventricular end-diastolic pressure in patients with chronic left-sided heart failure.
Plasma atrial natriuretic polypeptide as an index of left ventricular end-diastolic pressure in patients with chronic left-sided heart failure.
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血浆心房钠尿肽作为慢性左心衰竭患者左心室舒张末压的指标。
DOI：
10.1016/0002-8703(89)90734-5
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发表时间：
1989
影响因子：
4.8
通讯作者：
M. Kinoshita
中科院分区：
文献类型：
--
作者：
T. Tsutamoto;K. Bito;M. Kinoshita
为探讨心房利钠多肽(ANP)与血流动力学参数、血浆儿茶酚胺的关系，以及循环ANP是否在肺循环中代谢，测定了40例慢性左心衰患者的血浆ANP浓度。患者卧床至少30分钟后，同时从主肺动脉和升主动脉采集血样，然后注射造影剂。血浆心钠素浓度从Mpa到Ao显著降低(135.3±18.1pg/mlvs 127.4±19.4pg/ml；均值±扫描电子显微镜，p<；0.05)。血浆心钠素水平与AO患者血浆去甲肾上腺素水平、右心房压、平均肺毛细血管嵌压(r=0.829，p；0.001)、左心室舒张末压(r=0.88，p<；0.001)呈正相关。在AO的各种血流动力学参数和血浆儿茶酚胺浓度中，只有LVEDP被发现是MAPA血浆心钠素水平的独立和显著的预测因子。这些结果表明，在左心衰竭时，心脏释放的ANP主要受前负荷(LVEDP)的调节，循环ANP在肺循环中代谢。结论：血浆ANP浓度可作为慢性左心衰患者LVEDP的无创性检测指标。
To evaluate the relationship between plasma atrial natriuretic polypeptide (ANP), hemodynamic parameters, and plasma catecholamines and, in addition, to determine whether circulating ANP is metabolized in the pulmonary circulation, plasma concentrations of ANP were determined in 40 patients with chronic left-sided heart failure. After at least 30 minutes of bed rest with the patient in the supine position, blood samples were drawn simultaneously from both the main pulmonary artery (mPA) and the ascending aorta (Ao) before administration of contrast medium. The plasma ANP concentrations significantly decreased from the mPA to the Ao (135.3 ± 18.1 pg/ml vs 127.4 ± 19.4 pg/ml; mean ± SEM,p< 0.05). The plasma ANP level in the mPA correlated with the plasma norepinephrine level in the Ao (r= 0.71, p < 0.01), right atrial pressure (r= 0.34, p < 0.05), mean pulmonary capillary wedge pressure (r= 0.829, p < 0.001), and left ventricular end-diastolic pressure (LVEDP) (r= 0.88, p < 0.001). Of the various hemodynamic parameters and plasma catecholamine concentrations in the Ao, only LVEDP was found to be an independent and significant predictor of plasma ANP levels in the mPA. These results indicate that ANP released from the heart is regulated mainly by preload (LVEDP) in cases of left-sided heart failure and that circulating ANP is metabolized in the pulmonary circulation. In conclusion, the plasma ANP concentration may be a useful noninvasive index of LVEDP in patients with chronic left-sided heart failure.
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人体免疫反应性心房钠尿激素血浆水平与血流动力学功能之间的关系。
影响因子：
37.8
作者：
Bates,ER;Shenker,Y;Grekin,RJ
通讯作者：
Grekin,RJ
大鼠心肌梗死后慢性心力衰竭发展过程中心房钠尿肽水平。
影响因子：
6.1
作者：
Lee,RW;Gay,RG;Moffett,C;Johnson,DG;Goldman,S
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心房钠尿因子受体的三种不同形式：肾小管上皮细胞和血管平滑肌细胞含有不同类型的受体。
DOI：
10.1016/s0006-291x(87)80189-4
发表时间：
1987
影响因子：
3.1
作者：
Pandey,KN;Inagami,T;Misono,KS
通讯作者：
Misono,KS
影响因子：
158.5
作者：
COHN, JN;LEVINE, TB;RECTOR, T
通讯作者：
RECTOR, T