Evolution of vertebrate tissues driven by differential modes of gene duplication.
Evolution of vertebrate tissues driven by differential modes of gene duplication.
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DOI：
10.1093/dnares/dss012
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Makino T
中科院分区：
文献类型：
--
作者：
Satake M;Kawata M;McLysaght A;Makino T
在这项研究中，我们通过检查基因表达、复制和碱基替换模式之间的潜在关联来研究脊椎动物组织的进化。特别是，我们比较了全基因组复制（WGD）与小规模复制（SSD），以及受普遍表达基因限制的组织。所有模式还根据基因进化速率进行了分析。在那些以快速进化为特征并在有限范围的组织中表达的基因中，SSD所占的比例高于WGD。相反，普遍表达的基因与较慢的进化速度和较大比例的 WGD 相关。结果还表明，内胚层组织表达的基因的进化速度较快，外胚层基因的进化速度较慢。因此，SSD和WGD基因的比例分别在内胚层和外胚层中最高。因此，快速进化的SSD基因可能有助于内胚层组织的更快进化，而进化相对缓慢的WGD基因可能有助于维持外胚层组织的基本特征。间充质组织在这方面占据中间位置，而血细胞观察到的模式是独特的。快速的组织进化可能与特定的基因复制模式（SSD）和响应外部环境的更快的分子进化有关。这些发现揭示了组织及其相应基因进化的一般模式。
In this study, we investigated the evolution of vertebrate tissues by examining the potential association among gene expression, duplication, and base substitution patterns. In particular, we compared whole-genome duplication (WGD) with small-scale duplication (SSD), as well as tissue restricted with ubiquitously expressed genes. All patterns were also analysed in the light of gene evolutionary rates. Among those genes characterized by rapid evolution and expressed in a restricted range of tissues, SSD was represented in a larger proportion than WGD. Conversely, genes with ubiquitous expression were associated with slower evolutionary rates and a larger proportion of WGD. The results also show that evolutionary rates were faster in genes expressed in endodermal tissues and slower in ectodermal genes. Accordingly, the proportion of the SSD and WGD genes was highest in the endoderm and ectoderm, respectively. Therefore, quickly evolving SSD genes might have contributed to the faster evolution of endodermal tissues, whereas the comparatively slowly evolving WGD genes might have functioned to maintain the basic characteristics of ectodermal tissues. Mesenchymal tissues occupied an intermediate position in this regard, whereas the patterns observed for haemocytes were unique. Rapid tissue evolution could be related to a specific gene duplication mode (SSD) and faster molecular evolution in response to exposure to the external environment. These findings reveal general patterns underlying the evolution of tissues and their corresponding genes.
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影响因子：
30.8
作者：
McLysaght, A;Hokamp, K;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
11.4
作者：
Makino, Takashi;Hokamp, Karsten;McLysaght, Aoife
通讯作者：
McLysaght, Aoife
影响因子：
11.4
作者：
Liao, Ben-Yang;Zhang, Jianzhi
通讯作者：
Zhang, Jianzhi
影响因子：
10.7
作者：
KUMA, K;IWABE, N;MIYATA, T
通讯作者：
MIYATA, T
影响因子：
7
作者：
Huminiecki, L;Wolfe, KH
通讯作者：
Wolfe, KH