Impact of nutritional factors on incident kidney stone formation: a report from the WHI OS.
Impact of nutritional factors on incident kidney stone formation: a report from the WHI OS.
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DOI：
10.1016/j.juro.2011.12.077
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
WHI Working Group
中科院分区：
文献类型：
--
作者：
Sorensen MD;Kahn AJ;Reiner AP;Tseng TY;Shikany JM;Wallace RB;Chi T;Wactawski-Wende J;Jackson RD;O'Sullivan MJ;Sadetsky N;Stoller ML;WHI Working Group
增加液体摄入，减少饮食中钠和动物蛋白的摄入被认为可以降低肾结石的风险，但钙摄入的作用是有争议的。我们评估了饮食因素与肾结石形成的关系。对来自前瞻性WHI OS（妇女健康倡议观察性研究）的78,293名妇女进行了二次分析，这些妇女没有肾结石病史，并完成了经验证的食物频率问卷。多变量逻辑回归分析用于确定人口统计学和饮食因素，以及补充剂的使用与肾结石事件的独立相关性。在573,575人年的随访中，共有1,952名女性（2.5%）报告了肾结石事件。调整肾结石风险因素后，膳食钙摄入量增加，肾结石发病风险降低5%至28%（p = 0.01），饮水量增加，肾结石发病风险降低13%至31%（p = 0.002）。相反，调整后，较高的饮食钠摄入量使肾结石的风险增加了11%至61%（p <0.001），其中摄入量最高的女性效果最明显。较高的体重指数独立地增加了肾结石发生的风险（校正OR 1.19-2.01，p <0.001）。多变量分析显示动物蛋白摄入与肾结石无关。这项研究增加了越来越多的证据，强调保持足够的液体和膳食钙摄入的重要性。膳食钙摄入量增加可显著降低患肾结石的风险。相反，过量的钠摄入会增加肾结石的风险，尤其是在摄入量最高的女性中。动物蛋白质摄入与肾结石无关。
Increased fluid intake, and decreased dietary sodium and animal protein intake are thought to reduce the risk of kidney stones but the role of calcium intake is controversial. We evaluated the relationship between dietary factors and incident kidney stone formation. Secondary analysis was done of 78,293 women from the prospective WHI OS (Women’s Health Initiative Observational Study) with no history of nephrolithiasis who completed the validated food frequency questionnaire. Multivariate logistic regression was used to determine demographic and dietary factors, and supplement use independently associated with incident kidney stones. Overall 1,952 women (2.5%) reported an incident kidney stone in 573,575 person-years of followup. The risk of incident kidney stones was decreased by 5% to 28% (p = 0.01) with higher dietary calcium intake and by 13% to 31% (p = 0.002) with higher water intake after adjusting for nephrolithiasis risk factors. Conversely higher dietary sodium intake increased the risk of nephrolithiasis by 11% to 61% (p <0.001) after adjustment with the most pronounced effect in women with the highest intake. Higher body mass index independently increased the risk of incident nephrolithiasis (adjusted OR 1.19–2.01, p <0.001). Animal protein intake was not associated with nephrolithiasis on multivariate analysis. This study adds to the growing evidence underscoring the importance of maintaining adequate fluid and dietary calcium intake. Greater dietary calcium intake significantly decreased the risk of incident kidney stones. In contrast, excess sodium intake increased the risk of incident nephrolithiasis, especially in women with the highest intake. Animal protein intake was not independently associated with nephrolithiasis.
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影响因子：
6.6
作者：
SAKHAEE, K;HARVEY, JA;PAK, CYC
通讯作者：
PAK, CYC
影响因子：
7.1
作者：
Wallace, Robert B.;Wactawski-Wende, Jean;Masaki, Kamal
通讯作者：
Masaki, Kamal
DOI：
10.1097/01.asn.0000146012.44570.20
发表时间：
2004-12-01
影响因子：
13.6
作者：
Taylor, EN;Stampfer, MJ;Curhan, GC
通讯作者：
Curhan, GC
影响因子：
19.6
作者：
BATAILLE, P;ACHARD, JM;SEBERT, JL
通讯作者：
SEBERT, JL
影响因子：
158.5
作者：
CURHAN, GC;WILLETT, WC;STAMPFER, MJ
通讯作者：
STAMPFER, MJ