Distribution and Incidence of Blood-Borne Infection among Blood Donors from Regional Transfusion Centers in Burkina Faso: A Comprehensive Study.
Distribution and Incidence of Blood-Borne Infection among Blood Donors from Regional Transfusion Centers in Burkina Faso: A Comprehensive Study.
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DOI：
10.4269/ajtmh.20-0601
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发表时间：
2021-02-22
期刊：
影响因子：
--
通讯作者：
Nagalo BM
中科院分区：
文献类型：
--
作者：
Wongjarupong N;Oli S;Sanou M;Djigma F;Kiba Koumare A;Yonli AT;Hassan MA;Mara K;Harmsen WS;Therneau T;Barro O;Vodounhessi G;Sawadogo S;Chamcheu JC;Simpore J;Roberts LR;Nagalo BM
在西非，血液传播感染的流行率很高。本研究旨在确定布基纳法索献血者中血源性感染的血清阳性率，包括B型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、艾滋病毒和梅毒。2009年至2013年，在布基纳法索的四个主要城市（瓦加杜古）和农村地区（博博迪乌拉索、法达恩古尔马和瓦希古亚）招募献血者。血清学检测包括B型肝炎表面抗原、抗-HCV、抗-HIV和快速血浆反应素试验用于筛选，并用ELISA确认。计算首次献血者的患病率。从重复献血者中计算发生率和剩余风险。共有166，681名献血者; 43，084人有≥ 2次献血。HBV、HCV、HIV和梅毒的总血清阳性率分别为13.4%、6.9%、2.1%和2.4%。HBV、HCV、HIV和梅毒感染的发病率（IR）分别为2，433、3，056、1，121和1，287/10万人-年。城市HBV和HCV感染率分别为12.9%和5.9%，农村分别为14.0%和8.0%，城市和农村的HBV和HCV感染率均低于农村（P <0.001），HIV感染率分别为2.1%和2.1%，P = 0.25。新发HBV、HCV、HIV和梅毒的IR分别为2.43、3.06、1.12和1.29/10万人-年。HBV的剩余风险为每268例献血中有1例，HCV的剩余风险为每181例献血中有1例，HIV的剩余风险为每1,480例献血中有1例。总之，这项来自布基纳法索四个献血点的综合研究显示，HBV和HCV血清阳性率和发生率较高，献血的剩余风险较高。
There is a high prevalence of blood-borne infections in West Africa. This study sought to determine the seroprevalence of blood-borne infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), HIV, and syphilis, in blood donors in Burkina Faso. Blood donors were recruited from 2009 to 2013 in four major cities in Burkina Faso of urban area (Ouagadougou) and rural area (Bobo Dioulasso, Fada N’Gourma, and Ouahigouya). Serology tests including hepatitis B surface antigen, anti-HCV, anti-HIV, and rapid plasma reagin test were used for screening and were confirmed with ELISA. Disease prevalence was calculated among first-time donors. Incidence and residual risk were calculated from repeat donors. There were 166,681 donors; 43,084 had ≥ 2 donations. The overall seroprevalence of HBV, HCV, HIV, and syphilis were 13.4%, 6.9%, 2.1%, and 2.4%, respectively. The incidence rates (IRs) of HBV, HCV, HIV, and syphilis infection were 2,433, 3,056, 1,121, and 1,287 per 100,000 person-years. There was lower seroprevalence of HBV and HCV in urban area than in rural area (12.9% versus 14.0%, P < 0.001; and 5.9% versus 8.0%, P < 0.001), and no difference in HIV (2.1% versus 2.1%, P = 0.25). The IRs of new HBV, HCV, HIV, and syphilis were 2.43, 3.06, 1.12, and 1.29 per 100,000 person-years, respectively. The residual risk was one per 268 donations for HBV, one per 181 donations for HCV, and one per 1,480 donations for HIV, respectively. In conclusion, this comprehensive study from four blood donation sites in Burkina Faso showed high HBV and HCV seroprevalence and incidence with high residual risk from blood donation.
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影响因子：
4.5
作者：
Okoroiwu, Henshaw Uchechi;Okafor, Ifeyinwa Maryann;Okpokam, Dorathy Chioma
通讯作者：
Okpokam, Dorathy Chioma
撒哈拉以南非洲城市贫困人口中艾滋病毒感染的高度高风险。
影响因子：
4.4
作者：
Magadi MA
通讯作者：
Magadi MA
影响因子：
5.1
作者：
Wongjarupong N;Yonli AT;Nagalo BM;Djigma FW;Somda SK;Hassan MA;Mohamed EA;Sorgho AP;Compaore TR;Soubeiga ST;Kiendrebeogo I;Sanou M;Diarra B;Yang HI;Chen CJ;Ouattara AK;Zohoncon TM;Martinson JJ;Buetow K;Chamcheu JC;Antwi SO;Borad MJ;Simpore J;Roberts LR
通讯作者：
Roberts LR
影响因子：
2.8
作者：
Zegeye, Elias Asfaw;Mbonigaba, Josue;Johns, Benjamin
通讯作者：
Johns, Benjamin
DOI：
10.11604/pamj.2018.30.44.14663
发表时间：
2018
期刊：
The Pan African medical journal
影响因子：
--
作者：
Yambasu EE;Reid A;Owiti P;Manzi M;Murray MJS;Edwin AK
通讯作者：
Edwin AK