Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
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DOI：
10.1002/mrm.25352
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发表时间：
2015-06
影响因子：
3.3
通讯作者：
Choi, Changho
中科院分区：
文献类型：
--
作者：
Madan, Akshay;Ganji, Sandeep K.;An, Zhongxu;Choe, Kevin S.;Pinho, Marco C.;Bachoo, Robert M.;Maher, Elizabeth M.;Choi, Changho
目的：探讨脑肿瘤组织中乳酸(Lac)的T2弛豫时间及其与肿瘤分级的关系。在58-268毫秒之间选择了8对点分辨光谱的亚回声时间组，并进行了数值和模体分析，用于Lac T2测量。采集了24例脑胶质瘤患者(13例低级别和11例高级别)的体内频谱，并用LC模型对其进行了数值计算的基谱分析。代谢物T2弛豫时间由多TE信号估计值与TE的单指数拟合得到。代谢物浓度由T2拟合的零TE外推法估算。Lac T2估计约为240ms，在低级别和高级别肿瘤之间没有显著差异。低级别和高级别的Lac浓度分别为4.1±3.4和7.0±4.7 mm，但差异无统计学意义。Lac T2在不同级别的胶质瘤中相似。这表明，这项研究的T2值可能适用于在脑肿瘤的一个子集中获得Lac的T2无松弛估计。
To evaluate the T2 relaxation time of lactate (Lac) in brain tumors and the correlation of the T2 and concentration with tumor grades. Eight pairs of the subecho time sets of point-resolved spectroscopy were selected between 58 and 268 ms, with numerical and phantom analyses, for Lac T2 measurement. In-vivo spectra were acquired from 24 subjects with gliomas (13 low grade and 11 high grade) and analyzed with LCModel using numerically-calculated basis spectra. The metabolite T2 relaxation time was obtained from monoexponential fitting of the multi-TE signal estimates versus TE. The metabolite concentration was estimated from the zero-TE extrapolation of the T2 fits. The Lac T2 was estimated to be approximately 240 ms, without a significant difference between low and high grade tumors. The Lac concentration was estimated to be 4.1±3.4 and 7.0±4.7 mM for low and high grades respectively, but the difference was not significant. The Lac T2 was similar among gliomas regardless of their tumor grades. This suggests that the T2 value from this study may be applicable to obtain the T2 relaxation-free estimates of Lac in a subset of brain tumors.
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影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
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3.3
作者：
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影响因子：
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