Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients.
Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients.
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DOI：
10.1007/s10439-010-0128-x
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发表时间：
2011-01
影响因子：
3.8
通讯作者：
Nelson, Sarah J.
中科院分区：
文献类型：
--
作者：
Park, Ilwoo;Chen, Albert P.;Zierhut, Matthew L.;Ozturk-Isik, Esin;Vigneron, Daniel B.;Nelson, Sarah J.
关键词：
本研究的目的是在3 T下实施新的乳酸盐编辑的3D 1H磁共振波谱成像（MRSI）序列，并证明使用该序列测量胶质瘤患者乳酸盐的可行性。在3T下实现了3D PRESS MRSI序列，该序列包括缩短的高带宽180°脉冲、新的双BASING乳酸编辑脉冲、高带宽非常选择性抑制（VSS）脉冲和回扫回波平面读出。使用体模优化PRESS体素的过度处方因子，以最大限度地减少化学位移伪影。在体模和志愿者中，将乳酸盐编辑的回扫序列与使用传统椭圆k空间采样的乳酸盐编辑的MRSI进行比较，然后应用于胶质瘤患者。结果表明，在9.5分钟的短扫描时间内检测乳酸的可行性，在幻影和患者。体素的过度处方产生较少的化学位移伪影，允许在大部分选定体积上检测乳酸盐。使用回扫编码的脑代谢物的归一化SNR与使用常规相位编码MRSI的脑代谢物的SNR相当。专门的乳酸编辑的3D MRSI序列能够在3T下检测脑肿瘤患者的乳酸。这项技术的实施意味着可以在常规临床环境中评估脑乳酸，以研究其作为预后和治疗反应标志物的潜力。
The purpose of this study was to implement a new lactate-edited 3D 1H magnetic resonance spectroscopic imaging (MRSI) sequence at 3 T and demonstrate the feasibility of using this sequence for measuring lactate in patients with gliomas. A 3D PRESS MRSI sequence incorporating shortened, high bandwidth 180° pulses, new dual BASING lactate-editing pulses, high bandwidth very selective suppression (VSS) pulses and a flyback echo-planar readout was implemented at 3 T. Over-prescription factor of PRESS voxels was optimized using phantom to minimize chemical shift artifacts. The lactate-edited flyback sequence was compared with lactate-edited MRSI using conventional elliptical k-space sampling in a phantom and volunteers, and then applied to patients with gliomas. The results demonstrated the feasibility of detecting lactate within a short scan time of 9.5 min in both phantoms and patients. Over-prescription of voxels gave less chemical shift artifacts allowing detection of lactate on the majority of the selected volume. The normalized SNR of brain metabolites using the flyback encoding were comparable to the SNR of brain metabolites using conventional phase encoding MRSI. The specialized lactate-edited 3D MRSI sequence was able to detect lactate in brain tumor patients at 3 T. The implementation of this technique means that brain lactate can be evaluated in a routine clinical setting to study its potential as a marker for prognosis and response to therapy.
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影响因子：
11.2
作者：
HERHOLZ, K;HEINDEL, W;HEISS, WD
通讯作者：
HEISS, WD
影响因子：
19.7
作者：
KUGEL, H;HEINDEL, W;FRIEDMANN, G
通讯作者：
FRIEDMANN, G
影响因子：
2.5
作者：
MACFALL, JR;PELC, NJ;VAVREK, RM
通讯作者：
VAVREK, RM
影响因子：
3.3
作者：
Nelson, SJ
通讯作者：
Nelson, SJ
DOI：
10.1006/jmrb.1996.0104
发表时间：
1996-07-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
He, QH;Bhujwalla, ZM;Glickson, JD
通讯作者：
Glickson, JD