Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors.
Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors.
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DOI：
10.1007/978-981-13-1286-1_1
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发表时间：
2018
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Han Y;Xia G;Wu Q
表达agouti相关蛋白（AgRP）的神经元，即所谓的饥饿神经元，通过促进寻找食物的行为来保护哺乳动物免受饥饿（Trends Neurosci 36:504-512, 2013）。现在越来越多的证据表明，这些饥饿感知神经元不仅激励动物觅食和进食，而且还通过抑制生长、繁殖和应激反应等需要大量能量的先天过程来帮助保存能量。研究进一步发现，AgRP神经元将负价信号传递给奖励和认知中心，从而参与寻找和获得食物的动机行为（Physiol Behav 190:34-42, 2017）。基因组编辑和神经技术的最新进展引发了对体重和食物反应行为调节的独特定义的神经元群和神经回路的升级研究（Nat biotechnology 32:34 47 - 355, 2014; Proc Natl Acad Sci 113, 2016）。在本章中，我们将回顾描述AgRP回路的功能组织及其影响摄取，觅食，动机和认知反应的相关信号成分的文献，这一框架重塑了我们对肥胖和饮食失调治疗的新希望和挑战的思考。
Neurons expressing agouti-related protein (AgRP), the so-called hunger neurons, protect mammals from starvation by promoting food-seeking behaviors (Trends Neurosci 36:504–512, 2013). Now an increasing amount of evidence show that these hunger-sensing neurons not only motivate animals to forage and ingest food but also help conserve energy by inhibiting innate processes that demand large amounts of energy such as growth, reproduction, and stress response. It has further been perceived that AgRP neurons transmit signals with negative valence to reward and cognitive centers so as to engage the motivational behavior toward seeking and obtaining foods (Physiol Behav 190:34–42, 2017). Recent advancement in genome editing and neurotechniques unleashed an escalated research of uniquely defined neuronal populations and neural circuits underlying the behavioral regulation of body weight and food responses (Nat Biotechnol 32:347–355, 2014; Proc Natl Acad Sci 113, 2016). In this chapter we will review literatures describing the functional organization of the AgRP circuit and its correlative signaling components that influence ingestive, foraging, motivational, and cognitive responses, a framework that reshaped our thinking toward the new hope and challenges in treatment of obesity and eating disorders.
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影响因子：
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作者：
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DOI：
10.1523/jneurosci.2246-11.2011
发表时间：
2011-07-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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