Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?
Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?
复制标题
实时超声弹性成像的半定量分析能否区分多囊卵巢综合征患者非酒精性脂肪肝的更多肝实质改变？
DOI：
10.20945/2359-3997000000119
复制
发表时间：
2019-03
影响因子：
1.7
通讯作者：
Yang, Dongzi
中科院分区：
文献类型：
--
作者：
Di, Na;Zhou, Xinchuan;Chen, Yaxiao;Zhao, Xiaomiao;Li, Lin;Jiang, Linlin;Luo, Baoming;Chen, Xiaoli;Yang, Dongzi
关键词：
摘要 目的：非酒精性脂肪肝是最常见的弥漫性肝病，患有多囊卵巢综合征的女性患病风险增加。本研究的目的是评估实时超声弹性成像半定量应变参数对多囊卵巢综合征患者非酒精性脂肪肝的诊断价值。对象和方法：35 例合并非酒精性脂肪肝的多囊卵巢综合征患者、70 例不合并非酒精性脂肪肝的多囊卵巢综合征患者和 70 例健康育龄女性对照。所有参与者均接受了超声检查和肝脏实时超声弹性成像的半定量分析。结果：主要半定量应变参数，例如平均应变值，在多囊卵巢综合征伴非酒精性脂肪肝病组、多囊卵巢综合征伴非酒精性脂肪肝病组和对照组之间存在显着差异（87.02±10.16 vs. 96.31±11.44 vs. 104.49±7.28，p < 0.001）。平均应变值低或高的两个亚组之间的临床和实验室参数存在显着差异。对于转氨酶升高的平均应变值的诊断价值，曲线下面积为0.808（范围0.721-0.895）。在多元线性回归分析中，多囊卵巢综合征、腰围和代谢综合征是与无非酒精性脂肪肝患者的平均应变值相关的独立独立因素。结论：半定量实时超声弹性成像分析可以更灵敏地区分多囊卵巢综合征患者肝实质改变。该方法对非酒精性脂肪肝的诊断价值需要进一步研究。
ABSTRACT Objective: Nonalcoholic fatty liver disease is the commonest diffuse liver disease, of which women with polycystic ovary syndrome are at an increased risk. The aim of the present study was to assess the diagnostic value of the semiquantitative strain parameters of real-time ultrasound elastography for nonalcoholic fatty liver disease in patients with polycystic ovary syndrome. Subjects and methods: Thirty-five polycystic ovary syndrome patients with nonalcoholic fatty liver disease, 70 polycystic ovary syndrome patients without nonalcoholic fatty liver disease, and 70 healthy female controls of reproductive age were included. All participants underwent ultrasonic examination and semiquantitative analysis of real-time ultrasound elastography of the liver. Results: Main semi quantitative strain parameters, such as average strain value, differed significantly among groups polycystic ovary syndrome with nonalcoholic fatty liver disease, polycystic ovary syndrome without nonalcoholic fatty liver disease, and control (87.02 ± 10.16 vs. 96.31 ± 11.44 vs. 104.49 ± 7.28, p < 0.001). Clinical and laboratory parameters differed significantly between the two subgroups with low or high average strain value. For diagnostic value of average strain value for elevated aminotransferase, the area under the curve was 0.808 (range 0.721-0.895). In multiple linear regression analysis, polycystic ovary syndrome, waist circumference, and metabolic syndrome were stand-alone independent factors associated with average strain value among subjects without nonalcoholic fatty liver disease. Conclusion: Semiquantitative real-time ultrasound elastography analysis could distinguish liver parenchyma alterations in patients with polycystic ovary syndrome more sensitively. The diagnostic value of the proposed method for nonalcoholic fatty liver disease need further research.
登录
查看更多内容
影响因子：
0.6
作者：
Ramezani-Binabaj M;Motalebi M;Karimi-Sari H;Rezaee-Zavareh MS;Alavian SM
通讯作者：
Alavian SM
影响因子：
3.7
作者：
Carlsen JF;Ewertsen C;Săftoiu A;Lönn L;Nielsen MB
通讯作者：
Nielsen MB
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
6.1
作者：
Chen, Xiaoli;Ni, Renmin;Yang, Dongzi
通讯作者：
Yang, Dongzi
影响因子：
6.7
作者：
Fauser, Bart C. J. M.;Tarlatzis, Basil C.;Barnhart, Kurt
通讯作者：
Barnhart, Kurt