Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task.
Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task.
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DOI：
10.1038/s41467-022-31440-y
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发表时间：
2022-06-25
影响因子：
16.6
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中科院分区：
文献类型：
--
作者：
新技能的获得有可能扰乱现有的网络功能。为了直接评估先前获得的皮质功能是否在学习过程中发生改变，小鼠在抽象任务中进行训练，其中使用与初级视觉皮层（V1）神经元耦合的光学脑机接口设备奖励选定的活动模式。使用双光子钙成像纵向记录兴奋性神经元。尽管在任务执行过程中局部神经活动发生了显着变化，但在训练背景之外评估的调谐特性和刺激编码并未受到干扰。同样，刺激调谐是稳定的神经元，保持反应后，不同的，视觉辨别训练任务。然而，视觉辨别训练增加了表征漂移的速率。我们的研究结果表明，虽然某些形式的知觉学习可能会修改个别神经元的刺激编码的贡献，新的技能学习是不是本质上破坏性的质量刺激表示在成人V1。在小鼠中使用光学脑计算机接口，作者证明了新技能的获得并不会对现有功能造成固有的破坏。这些发现表明，神经网络对与整合新信息相关的扰动具有鲁棒性。
Acquisition of new skills has the potential to disturb existing network function. To directly assess whether previously acquired cortical function is altered during learning, mice were trained in an abstract task in which selected activity patterns were rewarded using an optical brain-computer interface device coupled to primary visual cortex (V1) neurons. Excitatory neurons were longitudinally recorded using 2-photon calcium imaging. Despite significant changes in local neural activity during task performance, tuning properties and stimulus encoding assessed outside of the trained context were not perturbed. Similarly, stimulus tuning was stable in neurons that remained responsive following a different, visual discrimination training task. However, visual discrimination training increased the rate of representational drift. Our results indicate that while some forms of perceptual learning may modify the contribution of individual neurons to stimulus encoding, new skill learning is not inherently disruptive to the quality of stimulus representation in adult V1. Using an optical brain computer interface in mice, here the authors demonstrate that new skill acquisition is not inherently disruptive to existing function. These findings suggest neural networks are robust to perturbations associated with integrating new information.
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