Effects of anesthetics on the renal sympathetic response to anaphylactic hypotension in rats.
Effects of anesthetics on the renal sympathetic response to anaphylactic hypotension in rats.
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DOI：
10.1371/journal.pone.0113945
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shibamoto T
中科院分区：
文献类型：
--
作者：
Sun L;Tanida M;Wang M;Kuda Y;Kurata Y;Shibamoto T
自主神经系统在大鼠过敏性低血压中起重要作用。众所周知，麻醉药会影响交感神经活动和心血管功能。然而，不同类型的麻醉对过敏性低血压时传出肾交感神经活动(RSNA)的影响尚不清楚。因此，我们测定了麻醉和清醒大鼠肾脏对过敏性低血压的交感反应，以及压力感受器在这些反应中的作用。SD大鼠被随机分为麻醉组和清醒组，麻醉组给予戊巴比妥钠、氨基甲酸乙酯或氯胺酮-赛拉津。大鼠皮下注射卵白蛋白致敏。测定体循环动脉压(SAP)、呼吸频率(RSNA)和心率(HR)。在戊巴比妥钠麻醉清醒大鼠上，观察去窦主动脉压力感受器神经对过敏反应时RSNA的影响。致敏大鼠注射抗原后，RSNA升高，SAP降低。在注射抗原后35min内的早期阶段，清醒大鼠的交感神经兴奋性显著高于麻醉大鼠。与麻醉大鼠相比，清醒大鼠的过敏性低血压有所减轻。麻醉对SAP和RSNA的抑制作用依次为氯胺酮-赛拉津和 = ；氨基甲酸乙酯-戊巴比妥。事实上，在接受氯胺酮-赛拉津治疗的大鼠中，RSNA直到40分钟才增加，SAP在注射抗原后保持在低水平。与清醒大鼠相比，麻醉大鼠的压力感受性反射受到抑制。压力感受性反射是通过增加RSNA和HR来评价的。与这一发现一致的是，去压力感受器神经可以减弱清醒大鼠RSNA对过敏反应的兴奋反应，但不能减弱戊巴比妥钠麻醉大鼠的兴奋反应。清醒大鼠在过敏性低血压时RSNA显著升高。麻醉药通过抑制压力感受器功能来减弱这种抗原诱导的肾交感兴奋。
The autonomic nervous system plays an important role in rat anaphylactic hypotension. It is well known that sympathetic nerve activity and cardiovascular function are affected by anesthetics. However, the effects of different types of anesthesia on the efferent renal sympathetic nerve activity (RSNA) during anaphylactic hypotension remain unknown. Therefore, we determined the renal sympathetic responses to anaphylactic hypotension in anesthetized and conscious rats and the roles of baroreceptors in these responses. Sprague-Dawley rats were randomly allocated to anesthetic groups that were given pentobarbital, urethane, or ketamine-xylazine and to a conscious group. The rats were sensitized using subcutaneously injected ovalbumin. The systemic arterial pressure (SAP), RSNA and heart rate (HR) were measured. The effects of sinoaortic baroreceptor denervation on RSNA during anaphylaxis were determined in pentobarbital-anesthetized and conscious rats. In all of the sensitized rats, the RSNA increased and SAP decreased after antigen injection. At the early phase within 35 min of the antigen injection, the antigen-induced sympathoexcitation in the conscious rats was significantly greater than that in the anesthetized rats. Anaphylactic hypotension was attenuated in the conscious rats compared to the anesthetized rats. The anesthetic-induced suppression of SAP and RSNA was greater in the order ketamine-xylazine >urethane = pentobarbital. Indeed, in the rats treated with ketamine-xylazine, RSNA did not increase until 40 min, and SAP remained at low levels after the antigen injection. The baroreceptor reflex, as evaluated by increases in RSNA and HR in response to the decrease in SAP induced by sodium nitroprusside (SNP), was suppressed in the anesthetized rats compared with the conscious rats. Consistent with this finding, baroreceptor denervation attenuated the excitatory responses of RSNA to anaphylaxis in the conscious rats but not in the pentobarbital-anesthetized rats. RSNA was increased markedly in conscious rats during anaphylactic hypotension. Anesthetics attenuated this antigen-induced renal sympathoexcitation through the suppression of baroreceptor function.
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影响因子：
2.7
作者：
Helwig, Bryan G.;Craig, Robin A.;Kenney, Michael J.
通讯作者：
Kenney, Michael J.
DOI：
10.1016/0165-1838(91)90106-d
发表时间：
1991-11-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
WATKINS, L;MAIXNER, W
通讯作者：
MAIXNER, W
影响因子：
2.7
作者：
Akine, A;Suzuka, H;Kato, Y
通讯作者：
Kato, Y
影响因子：
2.5
作者：
MEELEY, MP;RUGGIERO, DA;REIS, DJ
通讯作者：
REIS, DJ
DOI：
10.1152/ajpheart.00368.2005
发表时间：
2005-10-01
影响因子：
4.8
作者：
Shibamoto, T;Cui, S;Kurata, Y
通讯作者：
Kurata, Y