Hypoactivation in the precuneus and posterior cingulate cortex during ambiguous decision making in individuals with HIV.
Hypoactivation in the precuneus and posterior cingulate cortex during ambiguous decision making in individuals with HIV.
复制标题
HIV感染者在模糊决策过程中楔前叶和扣带后皮质的低激活。
DOI：
10.1007/s13365-021-00981-1
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发表时间：
2021-06
影响因子：
3.2
通讯作者：
Meade CS
中科院分区：
文献类型：
--
作者：
Hall SA;Towe SL;Nadeem MT;Hobkirk AL;Hartley BW;Li R;Huettel SA;Meade CS
人类免疫缺陷病毒(HIV)携带者通常会有神经认知障碍。艾滋病毒携带者在结果概率已知的情况下做出风险更高的决定，并且有异常的神经结构支撑着高风险的决策。然而，当结果概率未知时，模棱两可的决策在日常生活中更为常见，但艾滋病毒携带者做出模棱两可决策的神经结构尚不清楚。18名艾滋病毒携带者和20名对照组在接受功能性磁共振成像扫描的同时完成了一项决策任务。参与者在确定的奖励和不确定的奖励之间进行选择，其中获胜的概率是已知的(有风险的)或未知的(模糊的)。有三个风险级别：高、中、低。模棱两可>；危险的大脑活动在两组之间进行了比较。HIV携带者危险的大脑活动与情绪/精神功能相关。这两组人都同样厌恶模棱两可。艾滋病毒携带者比对照组更厌恶风险，更少选择高风险、不确定的选择。HIV携带者在进行模糊和中等风险的决策时，在楔前叶、扣带回后部和梭状回活动不足。在HIV携带者中，中等风险的大脑活动与情绪/精神功能呈负相关。为了做出模棱两可的决定，艾滋病毒携带者低估了默认模式网络的关键区域，这些区域被认为整合了内部和外部获得的信息，以做出决定。这些区域和相关的认知过程可能是改善艾滋病毒携带者决策结果的干预措施的候选者。
People with human immunodeficiency virus (HIV) often have neurocognitive impairment. People with HIV make riskier decisions when the outcome probabilities are known, and have abnormal neural architecture underlying risky decision making. However, ambiguous decision making, when the outcome probabilities are unknown, is more common in daily life, but the neural architecture underlying ambiguous decision making in people with HIV is unknown. Eighteen people with HIV and 20 controls completed a decision making task while undergoing functional magnetic resonance imaging scanning. Participants chose between a certain reward and uncertain reward with a known (risky) or unknown (ambiguous) probability of winning. There were three levels of risk: high, medium, and low. Ambiguous > risky brain activity was compared between groups. Ambiguous > risky brain activity was correlated with emotional/psychiatric functioning in people with HIV. Both groups were similarly ambiguity-averse. People with HIV were more risk-averse than controls and chose the high-risk uncertain option less often. People with HIV had hypoactivity in the precuneus, posterior cingulate cortex (PCC), and fusiform gyrus during ambiguous > medium risk decision making. Ambiguous > medium risk brain activity was negatively correlated with emotional/psychiatric functioning in individuals with HIV. To make ambiguous decisions, people with HIV underrecruit key regions of the default mode network, which are thought to integrate internally and externally derived information to come to a decision. These regions and related cognitive processes may be candidates for interventions to improve decision-making outcomes in people with HIV.
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影响因子：
3.7
作者：
Connolly CG;Bischoff-Grethe A;Jordan SJ;Woods SP;Ellis RJ;Paulus MP;Grant I;Translational Methamphetamine AIDS Research Center (TMARC) Group
通讯作者：
Translational Methamphetamine AIDS Research Center (TMARC) Group
影响因子：
3.2
作者：
Baker, Laurie M.;Paul, Robert H.;Ances, Beau M.
通讯作者：
Ances, Beau M.
DOI：
10.1007/s00406-012-0330-y
发表时间：
2013-04-01
影响因子：
4.7
作者：
Fond, Guillaume;Bayard, Sophie;Raffard, Stephane
通讯作者：
Raffard, Stephane
影响因子：
3.7
作者：
Brevers D;Cleeremans A;Verbruggen F;Bechara A;Kornreich C;Verbanck P;Noël X
通讯作者：
Noël X
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor