Potential and limitation of HLA-based banking of human pluripotent stem cells for cell therapy.
Potential and limitation of HLA-based banking of human pluripotent stem cells for cell therapy.
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DOI：
10.1155/2014/518135
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发表时间：
2014
影响因子：
4.1
通讯作者：
Villard J
中科院分区：
文献类型：
--
作者：
de Rham C;Villard J
人们对人类多能干细胞（hPS）的治疗寄予厚望。来自hPS细胞的组织或器官可能是治疗许多不同人类疾病的最佳解决方案，特别是那些对标准药物或药物无效的疾病，如神经退行性疾病、心力衰竭或糖尿病。hPS的起源是至关重要的，创建一个具有良好特征的hPS细胞库的想法已经出现，就像已经存在的脐带血一样。然而，移植的主要障碍是受者对组织或器官的排斥反应，这主要是由于三种主要的免疫屏障：人类白细胞抗原（HLA）、ABO血型和次要抗原。这个问题可以通过使用直接从患者身上提取的自体干细胞来解决，比如诱导多能干细胞（iPS）。但是iPS细胞有其局限性，特别是考虑到受体的疾病以及处理或制备自体iPS细胞可能存在的困难。最后，达到良好临床或生产规范的标准可能具有挑战性。这就是为什么特性良好且通用的hPS细胞可能是更好的解决方案。本文将讨论建立hPS细胞库的兴趣和可行性，以及一些经济和伦理问题。
Great hopes have been placed on human pluripotent stem (hPS) cells for therapy. Tissues or organs derived from hPS cells could be the best solution to cure many different human diseases, especially those who do not respond to standard medication or drugs, such as neurodegenerative diseases, heart failure, or diabetes. The origin of hPS is critical and the idea of creating a bank of well-characterized hPS cells has emerged, like the one that already exists for cord blood. However, the main obstacle in transplantation is the rejection of tissues or organ by the receiver, due to the three main immunological barriers: the human leukocyte antigen (HLA), the ABO blood group, and minor antigens. The problem could be circumvented by using autologous stem cells, like induced pluripotent stem (iPS) cells, derived directly from the patient. But iPS cells have limitations, especially regarding the disease of the recipient and possible difficulties to handle or prepare autologous iPS cells. Finally, reaching standards of good clinical or manufacturing practices could be challenging. That is why well-characterized and universal hPS cells could be a better solution. In this review, we will discuss the interest and the feasibility to establish hPS cells bank, as well as some economics and ethical issues.
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影响因子：
--
作者：
Klitz W;Gragert L;Maiers M;Tu B;Lazaro A;Yang R;Xu Q;Masaberg C;Ng J;Hurley CK
通讯作者：
Hurley CK
影响因子：
20.3
作者：
Loh, Yuin-Han;Agarwal, Suneet;Daley, George Q.
通讯作者：
Daley, George Q.
DOI：
10.1073/pnas.0911647107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Kuroda, Yasumasa;Kitada, Masaaki;Dezawa, Mari
通讯作者：
Dezawa, Mari
影响因子：
5.2
作者：
Li, L;Baroja, ML;Bhatia, M
通讯作者：
Bhatia, M
影响因子：
5.2
作者：
Nakajima, Fumiaki;Tokunaga, Katsushi;Nakatsuji, Norio
通讯作者：
Nakatsuji, Norio