Dopamine in the nucleus accumbens modulates the memory of social defeat in Syrian hamsters (Mesocricetus auratus).
Dopamine in the nucleus accumbens modulates the memory of social defeat in Syrian hamsters (Mesocricetus auratus).
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DOI：
10.1016/j.bbr.2015.02.030
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发表时间：
2015-06-01
影响因子：
2.7
通讯作者：
Huhman, K. L.
中科院分区：
文献类型：
--
作者：
Gray, C. L.;Norvelle, A.;Larkin, T.;Huhman, K. L.
条件性失败（CD）是叙利亚仓鼠经历社会失败后的一种行为反应。随后，被击败的仓鼠不再产生领土侵略，而是表现出更高的回避和提交水平，即使面对一个较小的，非侵略性的入侵者。多巴胺在脑桥核被假设作为一个信号的显着性奖励和厌恶刺激，以促进记忆的形成和适当的行为反应的重大事件。本研究的目的是验证这一假设，多巴胺在脑桥核调节的收购和表达的行为反应的社会失败。在Exp. 1.在失败训练前5分钟，双侧丘脑背核内注入非特异性D1/D2受体拮抗剂顺式氟哌噻吨（3.75 μg/150 nl生理盐水），显著减少了24小时后对非攻击性入侵者的顺从和防御行为。在Exp. 2，在用非攻击性入侵者进行条件性失败测试之前5分钟输注3.75 μg顺式（z）氟哌噻吨显著增加了药物输注受试者的攻击行为。在Exp. 3，我们发现顺式（Z）氟哌噻吨对攻击性的影响是特定于被击败的动物，因为将药物注入非被击败动物的丘脑核中并没有显著改变它们对非攻击性入侵者的反应行为。这些数据表明，多巴胺在脑桥核调节收购和表达的社会压力引起的行为变化，并建议，脑桥核起着重要的作用，在抑制侵略后，观察到社会失败。
Conditioned defeat (CD) is a behavioral response that occurs in Syrian hamsters after they experience social defeat. Subsequently, defeated hamsters no longer produce territorial aggression but instead exhibit heightened levels of avoidance and submission, even when confronted with a smaller, non-aggressive intruder. Dopamine in the nucleus accumbens is hypothesized to act as a signal of salience for both rewarding and aversive stimuli to promote memory formation and appropriate behavioral responses to significant events. The purpose of the present study was to test the hypothesis that dopamine in the nucleus accumbens modulates the acquisition and expression of behavioral responses to social defeat. In Exp. 1, bilateral infusion of the non-specific D1/D2 receptor antagonist cis(z)flupenthixol (3.75 μg/150 nl saline) into the nucleus accumbens 5 min prior to defeat training significantly reduced submissive and defensive behavior expressed 24 hr later in response to a non-aggressive intruder. In Exp. 2, infusion of 3.75 μg cis(z)flupenthixol 5 min before conditioned defeat testing with a non-aggressive intruder significantly increased aggressive behavior in drug-infused subjects. In Exp. 3, we found that the effect of cis(z)flupenthixol on aggression was specific to defeated animals as infusion of drug into the nucleus accumbens of non-defeated animals did not significantly alter their behavior in response to a non-aggressive intruder. These data demonstrate that dopamine in the nucleus accumbens modulates both acquisition and expression of social stress-induced behavioral changes and suggest that the nucleus accumbens plays an important role in the suppression of aggression that is observed after social defeat.
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DOI：
10.1523/jneurosci.6588-10.2011
发表时间：
2011-04-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ito R;Hayen A
通讯作者：
Hayen A
DOI：
10.1126/science.1249240
发表时间：
2014-04-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Friedman AK;Walsh JJ;Juarez B;Ku SM;Chaudhury D;Wang J;Li X;Dietz DM;Pan N;Vialou VF;Neve RL;Yue Z;Han MH
通讯作者：
Han MH
影响因子：
4.1
作者：
Corrigan, F. M.;Fisher, J. J.;Nutt, D. J.
通讯作者：
Nutt, D. J.
影响因子：
3.3
作者：
Drury, Stacy S.;Theall, Katherine P.;Keats, Bronya J. B.;Scheeringa, Michael
通讯作者：
Scheeringa, Michael
影响因子：
3.5
作者：
Huhman, KL;Solomon, MB;Jasnow, AM
通讯作者：
Jasnow, AM