The rewarding effects of alcohol after bariatric surgery: do they change and are they associated with pharmacokinetic changes?
The rewarding effects of alcohol after bariatric surgery: do they change and are they associated with pharmacokinetic changes?
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DOI：
10.1016/j.soard.2021.08.011
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Steffen K
中科院分区：
文献类型：
--
作者：
Engel SG;Schaefer LM;Kerver GA;Leone LM;Smith G;Mitchell JE;Gunstad J;Crosby RD;Steffen K
研究表明，接受过Roux-en-Y胃旁路术（RYGB）的手术患者患酒精使用障碍（AUD）的风险增加。然而，人们对这种风险增加的机制知之甚少。已经提出了一系列变量作为发展AUD的潜在因果关系，但缺乏对人类样本中许多变量的实证检验。我们的目的是检查酒精药代动力学（PK）的程度，酒精的奖励作用，以及这些变量之间的关系从减肥手术前后的变化。美国中西部的大型医疗机构34名参与者在RYGB之前和之后一年完成了评估。他们完成了实验室会议，并提供了关于酒精PK的数据，以及酒精在每个时间点对他们的强化程度。研究结果表明，酒精的PK效应（p<.01）和酒精的奖励程度（p<.01）在减肥手术后一年发生了变化。此外，从术前到术后一年，这些变量之间的相关性在统计学上显著增加（p<0.01）。这些结果表明，酒精的强化和PK效应的变化（从术前到术后一年）可能是Roux-en-Y胃旁路手术后酒精使用障碍风险增加的机制。
Research shows that surgery patients who have undergone Roux-en-Y gastric bypass (RYGB) are at increased risk for an alcohol use disorder (AUD). However, the mechanisms through which this increased risk is incurred are poorly understood. A host of variables have been proposed as potentially causal in developing AUDs, but empirical examination of many of these variables in human samples is lacking. Our objective was to examine the extent to which alcohol pharmacokinetics (PK), the rewarding effects of alcohol, and the relationship between these variables change from before to after weight loss surgery. Large healthcare facility in the Midwest United States Thirty-four participants completed assessments prior to, and one year after, RYGB. They completed laboratory sessions and provided data on the PK of alcohol and the extent to which alcohol was reinforcing to them at each timepoint. Findings show that the PK effects of alcohol (p<.01) and how rewarding alcohol was reported to be (p<.01) changed after from before, to one year after weight loss surgery. Further, statistically significant increases in the association between these variables were witnessed from before to one year after surgery (p<.01). These results implicate changes (from before surgery to one year after) in the reinforcing and PK effects of alcohol as possible mechanisms for increased risk of alcohol use disorder following Roux-en-Y gastric bypass surgery.
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