Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy.
Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy.
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DOI：
10.1016/j.jvir.2008.06.008
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发表时间：
2008-10
影响因子：
2.9
通讯作者：
Geschwind, Jean-Francois H.
中科院分区：
文献类型：
--
作者：
Lee, Kwang-Hun;Liapi, Eleni;Vossen, Josephina A.;Buijs, Manon;Ventura, Veronica Prieto;Georgiades, Christos;Hong, Kelvin;Kamel, Ihab;Torbenson, Michael S.;Geschwind, Jean-Francois H.
测试在肝癌动物模型中动脉内注射时是否可以通过专用磁共振（MR）成像检测到不同大小的含氧化铁Embosphere（IOE）颗粒，以及在组织病理学分析确认之前是否可以通过MR成像准确预测它们的分布。 20 只植入 VX2 肝肿瘤的新西兰白兔被随机分配接受 100 –300 µm 颗粒（S 组；n = 10）或 300 –500 µm 颗粒（L 组；n = 10）栓塞。将导管放置在肝固有动脉中进行栓塞。术后 24 小时内进行 T2* 加权多平面 MR 成像，以检测顺磁 IOE 磁化率伪影。 MR 成像解释参数包括动脉和/或肿瘤床中是否存在伪影。还获得了苏木精和伊红以及普鲁士蓝染色的病理切片，并类似地评估了 IOE 的存在。两组 IOE 的 MR 检出率均为 100%。在 30% 的 S 组动物中检测到肿瘤内部的顺磁磁化率 IOE 伪影。病理分析显示，该组70%的肿瘤内检测到IOE颗粒。 MR 成像和组织病理学研究发现 L 组 IOE 位于肝动脉内肿瘤外（P < .05）。磁共振成像很容易在肝癌动物模型中检测到 IOE 颗粒，无论颗粒大小如何。较小的颗粒（100 – 300 µm）被输送到肿瘤内部或靠近肿瘤边缘，证明它们用于药物输送或精确栓塞是合理的。
To test whether different-sized iron oxide– containing Embosphere (IOE) particles can be detected by dedicated magnetic resonance (MR) imaging when injected intraarterially in an animal model of liver cancer and whether their distribution could be accurately predicted by MR imaging before confirmation with histopathologic analysis. Twenty New Zealand White rabbits implanted with VX2 liver tumor were randomly assigned to undergo embolization with 100 –300-µm particles (group S; n = 10) or 300 –500-µm particles (group L; n = 10). Embolization was performed with the catheter placed in the proper hepatic artery. T2*-weighted multiplanar MR imaging was performed within 24 hours after the procedure to detect paramagnetic IOE susceptibility artifact. MR imaging interpretation parameters included presence of artifact in the artery and/or at the tumor bed. Hematoxylin and eosin– and Prussian blue–stained pathologic slides were also obtained and the presence of IOE was evaluated similarly. The MR detectability rates for IOEs were 100% in both groups. Paramagnetic susceptibility IOE artifact inside the tumor was detected in 30% of group S animals. On pathologic analysis, IOE particles were detected inside the tumor in 70% of this group. IOEs in group L were found outside the tumor within the hepatic artery on MR imaging and histopathologic study (P < .05). MR imaging readily detected IOE particles in an animal model of liver cancer regardless of the particle size. The smaller particles (100 –300 µm) were delivered inside the tumor or in close proximity to the tumor margin, justifying their use for drug delivery or precise embolization.
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影响因子：
3.5
作者：
Moroz, P;Metcalf, C;Gray, BN
通讯作者：
Gray, BN
DOI：
10.1007/s10856-006-0040-y
发表时间：
2008-02-01
影响因子：
3.7
作者：
Gonzalez, M. Victoria;Tang, Yiqing;Lewis, Andrew L.
通讯作者：
Lewis, Andrew L.
DOI：
10.1016/s0360-3016(97)00818-3
发表时间：
1998-02-01
影响因子：
7
作者：
Lau, WY;Ho, S;Li, AKC
通讯作者：
Li, AKC
DOI：
10.1097/01.rvi.0000184535.26360.5a
发表时间：
2005-12-01
影响因子：
2.9
作者：
Hong, K;Kobeiter, H;Geschwind, JFH
通讯作者：
Geschwind, JFH
DOI：
10.1097/01.rvi.0000161377.33557.20
发表时间：
2005-07-01
影响因子：
2.9
作者：
Maluccio, M;Covey, AM;Brown, KT
通讯作者：
Brown, KT