Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart.
Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart.
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DOI：
10.3390/vaccines9060652
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发表时间：
2021-06-15
期刊：
影响因子：
7.8
通讯作者：
Gobba F
中科院分区：
文献类型：
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作者：
Modenese A;Paduano S;Bargellini A;Bellucci R;Marchetti S;Bruno F;Grazioli P;Vivoli R;Gobba F
背景：在新冠肺炎大流行中，医护人员的免疫接种在预防中发挥着公认的关键作用：在意大利，疫苗接种运动于2020年12月底开始。更好地了解卫生工作者的现场免疫反应、不良反应和涉及的主要因素是根本。方法：我们对意大利北部一家疗养院的工作人员进行了一项研究，该疗养院于2021年1月至2月接种了两剂BNT162b2疫苗，间隔四周，而不是最初制造商协议中规定的三周。第二次免疫1个月后，检测SARS-CoV-2刺突蛋白S1亚基中和抗体的血清效价。调查对象的社会人口学特征、临床特征及接种疫苗的不良反应。结果：所有作业工人均有较高的抗体滴度，为最低保护水平的20~760倍。在既往有新冠肺炎诊断的受试者中，滴度明显更高。第二次接种疫苗后不良反应发生率较高，但未观察到严重不良反应。结论：两次接种BNT162b2疫苗，即使间隔四周，也能在所有纳入研究的操作者中诱导高滴度的抗SARS-CoV-2中和免疫球蛋白G。
Background: The immunization of healthcare workers (HCWs) plays a recognized key role in prevention in the COVID-19 pandemic: in Italy, the vaccination campaign began at the end of December 2020. A better knowledge of the on-field immune response in HCWs, of adverse effects and of the main factors involved is fundamental. Methods: We performed a study on workers at a nursing home in Northern Italy, vaccinated in January–February 2021 with two doses of the BNT162b2 vaccine four weeks apart, instead of the three weeks provided for in the original manufacturer protocol. One month after the second dose, the serological titer of IgG-neutralizing anti-RBD antibodies of the subunit S1 of the spike protein of SARS-CoV-2 was determined. The socio-demographic and clinical characteristics of the subjects and adverse effects of vaccination were collected by questionnaire. Results: In all of the workers, high antibody titer, ranging between 20 and 760 times the minimum protective level were observed. Titers were significantly higher in subjects with a previous COVID-19 diagnosis. Adverse effects after the vaccine were more frequent after the second dose, but no severe adverse effects were observed. Conclusions: The two doses of the BNT162b2 vaccine, even if administered four weeks apart, induced high titers of anti-SARS-CoV-2 neutralizing IgG in all the operators included in the study.
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影响因子：
7.3
作者：
Colucci M;Piano Mortari E;Zotta F;Corrente F;Concato C;Carsetti R;Emma F;Vivarelli M
通讯作者：
Vivarelli M
DOI：
10.1016/j.cca.2021.04.006
发表时间：
2021-08
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
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作者：
Padoan A;Dall'Olmo L;Rocca FD;Barbaro F;Cosma C;Basso D;Cattelan A;Cianci V;Plebani M
通讯作者：
Plebani M
DOI：
10.1002/dmrr.3465
发表时间：
2022-01
期刊：
Diabetes/metabolism research and reviews
影响因子：
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作者：
Watanabe M;Balena A;Tuccinardi D;Tozzi R;Risi R;Masi D;Caputi A;Rossetti R;Spoltore ME;Filippi V;Gangitano E;Manfrini S;Mariani S;Lubrano C;Lenzi A;Mastroianni C;Gnessi L
通讯作者：
Gnessi L
DOI：
10.26355/eurrev_202102_24877
发表时间：
2021-01-01
影响因子：
3.3
作者：
Meo, S. A.;Bukhari, I. A.;Klonoff, D. C.
通讯作者：
Klonoff, D. C.
DOI：
10.1016/s2666-5247(21)00088-4
发表时间：
2021-05
期刊：
The Lancet. Microbe
影响因子：
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作者：
通讯作者：
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