Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID-19 mRNA vaccine.
Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID-19 mRNA vaccine.
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DOI：
10.1002/dmrr.3465
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Gnessi L
中科院分区：
文献类型：
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作者：
Watanabe M;Balena A;Tuccinardi D;Tozzi R;Risi R;Masi D;Caputi A;Rossetti R;Spoltore ME;Filippi V;Gangitano E;Manfrini S;Mariani S;Lubrano C;Lenzi A;Mastroianni C;Gnessi L
探索与COVID-19 mRNA疫苗接种后血清学应答相关的变量。于二零二一年一月至二月，86名医护人员参加了COVID-19疫苗接种活动。所有受试者均接受了两次COVID-19 mRNA疫苗接种（辉瑞/BioNTech），间隔3周。在第1次接种前和第2次接种后1-4周收集血液样本。记录临床病史、人口统计学和疫苗副作用。测量基线人体测量参数，并通过双能X线吸收测定法测定身体组成。腰围越大，抗体滴度越低（R =-0.324，p = 0.004）;与非吸烟者相比，吸烟者的水平较低[1099（1350）vs. 1921（1375），p = 0.007]，高血压与正常血压相比[650 ± 1192 vs. 1911（1364），P = 0.001]和血脂异常[534（972）vs 1872（1406），p = 0.005]。多变量分析显示，腰围较大、吸烟、高血压和第二次疫苗接种后时间较长与抗体滴度较低相关，与BMI、年龄无关。和性别。向心性肥胖、高血压和吸烟与COVID-19疫苗接种后抗体滴度降低相关。虽然目前无法确定较低的SARS-CoV-2抗体是否会导致更高的COVID-19发生的可能性，但已经确定中和抗体与针对包括SARS-CoV-2在内的几种病毒的保护相关。因此，我们的研究结果要求采取警惕的方法，因为中心性肥胖、高血压和吸烟的受试者可以从早期疫苗加强剂或不同的疫苗接种时间表中获益。
To explore variables associated with the serological response following COVID‐19 mRNA vaccine. Eighty‐six healthcare workers adhering to the vaccination campaign against COVID‐19 were enrolled in January–February 2021. All subjects underwent two COVID‐19 mRNA vaccine inoculations (Pfizer/BioNTech) separated by 3 weeks. Blood samples were collected before the 1st and 1–4 weeks after the second inoculation. Clinical history, demographics, and vaccine side effects were recorded. Baseline anthropometric parameters were measured, and body composition was performed through dual‐energy‐X‐ray absorptiometry. Higher waist circumference was associated with lower antibody (Ab) titres (R = −0.324, p = 0.004); smokers had lower levels compared to non‐smokers [1099 (1350) vs. 1921 (1375), p = 0.007], as well as hypertensive versus normotensive [650 ± 1192 vs. 1911 (1364), p = 0.001] and dyslipideamic compared to those with normal serum lipids [534 (972) vs 1872 (1406), p = 0.005]. Multivariate analysis showed that higher waist circumference, smoking, hypertension, and longer time elapsed since second vaccine inoculation were associated with lower Ab titres, independent of BMI, age. and gender. Central obesity, hypertension, and smoking are associated with lower Ab titres following COVID‐19 vaccination. Although it is currently impossible to determine whether lower SARS‐CoV‐2 Abs lead to higher likelihood of developing COVID‐19, it is well‐established that neutralizing antibodies correlate with protection against several viruses including SARS‐CoV‐2. Our findings, therefore, call for a vigilant approach, as subjects with central obesity, hypertension, and smoking could benefit from earlier vaccine boosters or different vaccine schedules.
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影响因子：
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作者：
Qiu F;Liang CL;Liu H;Zeng YQ;Hou S;Huang S;Lai X;Dai Z
通讯作者：
Dai Z
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
3.6
作者：
Yumuk V;Tsigos C;Fried M;Schindler K;Busetto L;Micic D;Toplak H;Obesity Management Task Force of the European Association for the Study of Obesity
通讯作者：
Obesity Management Task Force of the European Association for the Study of Obesity
影响因子：
105.7
作者：
Petrilli, Christopher M.;Jones, Simon A.;Horwitz, Leora I.
通讯作者：
Horwitz, Leora I.
影响因子：
3.7
作者：
Watanabe, Mikiko;Masieri, Simonetta;Lubrano, Carla
通讯作者：
Lubrano, Carla