Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment.
Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment.
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DOI：
10.1016/j.crad.2017.04.021
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发表时间：
2017-11
影响因子：
2.6
通讯作者：
Halpin S
中科院分区：
文献类型：
--
作者：
Gan CL;O'Sullivan MJ;Metzler-Baddeley C;Halpin S
评估使用相邻间隔核之间的距离作为阿尔茨海默病 (AD) 中间隔区萎缩的替代标记。在不考虑临床细节的情况下，对在威尔士大学医院接受脑部计算机断层扫描 (CT) 的 250 名患者进行了间隔距离 (ISD) 测量。检索包括记忆问题历史在内的临床详细信息。我们寻求一个能够区分有记忆症状和没有记忆症状的人的 ISD 截止值。还对 20 名 AD 患者进行了 ISD 测量。为了测试该方法和定义的截止值，然后以随机和盲法的方式在由 21 名轻度认知障碍 (MCI) 患者和 45 名年龄匹配的健康对照组成的独立队列中进行测量。所有患者均获得 ISD 测量。在 28 名有记忆症状的患者中，平均 ISD 为 5.9 毫米，而没有明显症状的患者为 2.3 毫米 (p=0.001)。最佳 ISD 截止值为 4 mm（敏感性 85.7%，特异性 85.8%）。所有 AD 患者的 ISD > 4 mm（平均 ISD= 6.1 mm）。 MCI 患者的平均 ISD 为 3.84 mm，而年龄匹配的健康对照组为 2.18 mm (p=0.001)。使用 4 毫米截止值正确分类了 10 名轻度认知障碍患者 (47.6%) 和 38 名健康对照者 (84.4%)。 ISD 是一种简单可靠的间隔区萎缩替代测量方法，适用于 CT 和磁共振成像 (MRI)。它可用于帮助选择患者进行进一步调查。
To evaluate the use the distance between the adjacent septal nuclei as a surrogate marker of septal area atrophy seen in Alzheimer's disease (AD). Interseptal distance (ISD) was measured, blind to clinical details, in 250 patients who underwent computed tomography (CT) of the brain at University Hospital of Wales. Clinical details including memory problem history were retrieved. An ISD cut-off value that discriminated those with and without memory symptoms was sought. ISD measurements were also made in 20 AD patients. To test both the method and the defined cut-off, measurements were then made in an independent cohort of 21 mild cognitive impairment (MCI) patients and 45 age-matched healthy controls, in a randomised and blinded fashion. ISD measurement was achieved in all patients. In 28 patients with memory symptoms, the mean ISD was 5.9 mm compared with 2.3 mm in those without overt symptoms (p=0.001). The optimum ISD cut-off value was 4 mm (sensitivity 85.7% and specificity 85.8%). All AD patients had an ISD of >4 mm (mean ISD= 6.1 mm). The mean ISD for MCI patients was 3.84 mm compared with 2.18 mm in age-matched healthy controls (p=0.001). Using a 4 mm cut-off correctly categorised 10 mild cognitive impairment patients (47.6%) and 38 healthy controls (84.4%). ISD is a simple and reliable surrogate measurement for septal area atrophy, applicable to CT and magnetic resonance imaging (MRI). It can be used to help select patients for further investigation.
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DOI：
10.1007/s00259-002-0816-3
发表时间：
2002-07-01
影响因子：
9.1
作者：
Callen, DJA;Black, SE;Caldwell, CB
通讯作者：
Caldwell, CB
影响因子：
4
作者：
Mioshi, Eneida;Dawson, Kate;Hodges, John R.
通讯作者：
Hodges, John R.
DOI：
10.3174/ajnr.a2589
发表时间：
2011-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Hanseeuw BJ;Van Leemput K;Kavec M;Grandin C;Seron X;Ivanoiu A
通讯作者：
Ivanoiu A
影响因子：
9.9
作者：
Duara, R.;Loewenstein, D. A.;Potter, H.
通讯作者：
Potter, H.
影响因子：
4
作者：
Cherubini, Andrea;Peran, Patrice;Spalletta, Gianfranco
通讯作者：
Spalletta, Gianfranco