Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.
Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.
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DOI：
10.1371/journal.pone.0195883
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Hall KT
中科院分区：
文献类型：
--
作者：
Crum AJ;Akinola M;Turnwald BP;Kaptchuk TJ;Hall KT
有证据表明，改变压力心态相信压力会增强而不是削弱可以改变对压力的认知，情感和生理反应。然而，个体差异的反应压力心态操纵尚未探讨。考虑到先前确定的儿茶酚胺在安慰剂效应和压力中的作用，我们假设儿茶酚-O-甲基转移酶（COMT）（一种代谢儿茶酚胺的酶）的遗传变异将缓和对旨在改变参与者对压力的心态的干预的反应。参与者（N = 107）在参与特里尔社会压力任务和随后的认知任务之前暴露于压力心态操纵（强调压力的增强或削弱作用的视频）。COMT rs 4680多态性与压力心态视频操作对认知和情感反应的影响的关联进行了研究。rs 4680的遗传变异改变了压力心态对情感和认知压力反应的影响。rs 4680低活性等位基因（met/met）纯合子个体对“压力即增强”的心态操纵有反应，表现为积极情绪的增加、认知功能的改善和对压力的幸福偏见。相反，高活性等位基因（瓦尔/瓦尔）的纯合子个体对压力心态操纵没有反应。这些结果表明，对压力心态干预的反应可能会因COMT基因型而异。这些发现有助于理解基因与环境的相互作用对心态干预和压力反应的影响，因此值得进一步研究。
There is evidence that altering stress mindset—the belief that stress is enhancing vs. debilitating—can change cognitive, affective and physiological responses to stress. However individual differences in responsiveness to stress mindset manipulations have not been explored. Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants’ mindsets about stress. Participants (N = 107) were exposed to a stress mindset manipulation (videos highlighting either the enhancing or debilitating effects of stress) prior to engaging in a Trier Social Stress task and subsequent cognitive tasks. The associations of the COMT rs4680 polymorphism with the effect of stress mindset video manipulations on cognitive and affective responses were examined. Genetic variation at rs4680 modified the effects of stress mindset on affective and cognitive responses to stress. Individuals homozygous for rs4680 low-activity allele (met/met) were responsive to the stress-is-enhancing mindset manipulation as indicated by greater increases in positive affect, improved cognitive functioning, and happiness bias in response to stress. Conversely, individuals homozygous for the high-activity allele (val/val) were not as responsive to the stress mindset manipulation. These results suggest that responses to stress mindset intervention may vary with COMT genotype. These findings contribute to the understanding of gene by environment interactions for mindset interventions and stress reactivity and therefore warrant further investigations.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
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影响因子：
34.7
作者：
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通讯作者：
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影响因子：
3
作者：
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通讯作者：
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影响因子：
64.5
作者：
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影响因子：
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作者：
Gaunt, Tom R.;Rodriguez, Santiago;Day, Ian N. M.
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Day, Ian N. M.