The Effects of Three Types of Stress on Fos Expression in the Hypothalamic Paraventricular Nucleus, Hippocampus and Amygdala in Female Rats at Different Stages of Preg- nancy
The Effects of Three Types of Stress on Fos Expression in the Hypothalamic Paraventricular Nucleus, Hippocampus and Amygdala in Female Rats at Different Stages of Preg- nancy
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三种应激对不同妊娠阶段雌性大鼠下丘脑室旁核、海马和杏仁核 Fos 表达的影响
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Shoji Nakamura
中科院分区：
文献类型：
--
作者：
Masuo Tanaka;S. Hayashi;T. Fujioka;I. Tobe;Shoji Nakamura
免疫组化法检测Fos蛋白（神经元激活的标志物），本实验研究是否有不同的反应室旁核（PVN），海马和杏仁核的孕大鼠暴露于三种类型的应激（束缚、固定和通讯盒压力），在三个怀孕阶段都具有本质上不同的严重程度（妊娠6天，或P6，妊娠早期），P12（妊娠中期）和P18（妊娠晚期）。小细胞PVN被激活的所有三个压力几乎同样在所有怀孕阶段。大细胞PVN似乎变得更加活跃，没有压力，在怀孕中期比怀孕早期。孕中期海马齿状回对制动应激和通讯盒应激的反应以及基底外侧杏仁核对制动应激的反应均大于其他妊娠阶段。大细胞PVN在孕晚期对通讯盒应激的敏感性高于其他妊娠阶段，而海马CA3和内侧杏仁核在孕晚期对通讯盒应激和束缚应激的敏感性分别低于其他妊娠阶段。这些结果表明，怀孕雌性大鼠的PVN、海马和杏仁核对不同应激源的反应在不同的怀孕阶段是不同的。
Using immunohistochemistry to reveal the Fos protein (a marker of neu- ronal activation), the present experiments examined whether there were differences in the responses of the paraventricular nucleus (PVN), hippocampus, and amygdala of pregnant rats exposed to three types of stressors (restraint, immobilization, and communication-box stress), all having inherently different severities, at three preg- nancy stages (6 days into pregnancy, or P6, early-pregnancy), P12 (mid-pregnancy) and P18 (late-pregnancy). The parvocellular PVN was activated by all three stressors almost equally at all pregnancy stages. The magnocellular PVN appeared to become more active without stressors in mid-pregnancy than in early-pregnancy. The stress responses of the hippocampal dentate gyrus to immobilization and communication- box stress, and that of the basolateral amygdala to immobilization stress in pregnant females, were greater in mid-pregnancy than at the other pregnancy stages. The magnocellular PVN was more sensitive to communication-box stress in late-preg- nancy than at the other pregnancy stages, while the hippocampal CA3 and medial amygdala were less sensitive to communication-box stress and to restraint stress in late-pregnancy than at the other pregnancy stages, respectively. These results suggest that the responses of the PVN, hippocampus, and amygdala in pregnant female rats to different stressors were variable at different pregnancy stages.
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影响因子：
56.9
作者：
SAGAR, SM;SHARP, FR;CURRAN, T
通讯作者：
CURRAN, T
皮层和海马体的应激激活受到性别和发情阶段的调节。
DOI：
10.1210/endo.143.7.8888
发表时间：
2002
期刊：
Endocrinology.
影响因子：
--
作者：
Figueiredo,HelmerF;Dolgas,CharlesM;Herman,JamesP
通讯作者：
Herman,JamesP
影响因子：
6.1
作者：
GIBBS, DM
通讯作者：
GIBBS, DM
急性应激后立即早期基因的激活。
影响因子：
1.7
作者：
Schreiber,SS;Tocco,G;Shors,TJ;Thompson,RF
通讯作者：
Thompson,RF