Considerations for theoretical modelling of thermal ablation with catheter-based ultrasonic sources: implications for treatment planning, monitoring and control.
Considerations for theoretical modelling of thermal ablation with catheter-based ultrasonic sources: implications for treatment planning, monitoring and control.
复制标题
DOI：
10.3109/02656736.2011.630337
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Diederich CJ
中科院分区：
文献类型：
--
作者：
Prakash P;Diederich CJ
旨在确定加热期间组织物理特性的动态变化对基于导管的超声反馈控制热消融的影响。此外，我们比较了热损伤的几个指标对预测的消融区域范围的影响，以计划和监测使用这种模式的消融。使用结合基于温度的反馈控制的组织间和经尿道施用器的超声消融的3D模型来模拟前列腺和肝脏组织中的热消融。我们研究了五个耦合模型的热依赖性变化的组织声衰减/吸收和血液灌注的不同程度的复杂性。使用温度、热剂量和凝固性坏死的Arrhenius热损伤指标计算消融区的尺寸。在治疗计划设置中的患者特定解剖结构上对这些模型中的每一个的预测进行了比较。包括血液灌注和声衰减动态变化的模型作为热剂量/损伤的函数预测了几乎相同的消融区体积（最大变化< 2.5%）。考虑到动态声衰减似乎在估计消融区尺寸方面发挥了关键作用，因为使用恒定值的声衰减模型预测肝脏和前列腺组织中的消融区体积分别增加50%或减少47%。凝固性坏死的热剂量（t43 ≥ 240 min）和热损伤（Ω ≥ 4.6）阈值在所有加热持续时间内均具有良好的一致性，短时间（< 5 min）消融的温度阈值范围为54 °C，长时间（15 min）消融的温度阈值范围为50 °C，可作为确定外部治疗边界的替代值。考虑到声衰减/吸收的动态变化，似乎在消融区的预测范围中起着关键作用。对于使用该模式的典型5-15分钟消融，消融区尺寸的热剂量和Arrhenius损伤测量具有良好的一致性，而适当选择的温度阈值提供了计算上更便宜的替代物。
To determine the impact of including dynamic changes in tissue physical properties during heating on feedback controlled thermal ablation with catheter-based ultrasound. Additionally, we compared impact several indicators of thermal damage on predicted extents of ablation zones for planning and monitoring ablations with this modality. A 3D model of ultrasound ablation with interstitial and transurethral applicators incorporating temperature based feedback control was used to simulate thermal ablations in prostate and liver tissue. We investigated five coupled models of heat dependent changes in tissue acoustic attenuation/absorption and blood perfusion of varying degrees of complexity.. Dimensions of the ablation zone were computed using temperature, thermal dose, and Arrhenius thermal damage indicators of coagulative necrosis. A comparison of the predictions by each of these models was illustrated on a patient-specific anatomy in the treatment planning setting. Models including dynamic changes in blood perfusion and acoustic attenuation as a function of thermal dose/damage predicted near-identical ablation zone volumes (maximum variation < 2.5%). Accounting for dynamic acoustic attenuation appeared to play a critical role in estimating ablation zone size, as models using constant values for acoustic attenuation predicted ablation zone volumes up to 50% larger or 47% smaller in liver and prostate tissue, respectively. Thermal dose (t43 ≥ 240min) and thermal damage (Ω ≥ 4.6) thresholds for coagulative necrosis are in good agreement for all heating durations, temperature thresholds in the range of 54 °C for short (< 5 min) duration ablations and 50 °C for long (15 min) ablations may serve as surrogates for determination of the outer treatment boundary. Accounting for dynamic changes in acoustic attenuation/absorption appeared to play a critical role in predicted extents of ablation zones. For typical 5—15 min ablations with this modality, thermal dose and Arrhenius damage measures of ablation zone dimensions are in good agreement, while appropriately selected temperature thresholds provide a computationally cheaper surrogate.
登录
查看更多内容
影响因子：
3.5
作者：
Connor, CW;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
3.2
作者：
Bhattacharya, A;Mahajan, RL
通讯作者：
Mahajan, RL
影响因子：
2.4
作者：
DAMIANOU, C;HYNYNEN, K
通讯作者：
HYNYNEN, K
影响因子：
2.9
作者：
Bouchoux, Guillaume;Lafon, Cyril;Cathignol, Dominique
通讯作者：
Cathignol, Dominique
DOI：
10.1016/j.jvir.2010.07.022
发表时间：
2010-11-01
影响因子：
2.9
作者：
Fuentes, David;Cardan, Rex;Feng, Yusheng
通讯作者：
Feng, Yusheng