A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats.
A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats.
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DOI：
10.1155/2012/468764
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Abdulla MA
中科院分区：
文献类型：
--
作者：
Al-Bayaty F;Abdulla MA
背景和目的。本研究的目的是评价阿法替米德和二氧化氯凝胶对链脲佐菌素诱导的糖尿病大鼠伤口愈合的作用。实验方法。选择48只Sprague道利大鼠进行本研究，分为4组。糖尿病是诱发的。创建直径2厘米的全层皮肤切除伤口。动物每天局部给药两次。第1组，糖尿病对照组，用0.2 mL无菌蒸馏水处理。第2组作为参比标准品，用0.2 mL Intrasite凝胶处理。第3组和第4组分别用0.2 mL Aftamed和0.2 mL二氧化氯凝胶处理。在第10天切除肉芽组织并进行组织学和生化分析。测定谷胱甘肽过氧化物酶、超氧化物歧化酶活性和丙二醛（MDA）含量。结果Aftamed处理的伤口表现出显着增加羟脯氨酸，细胞增殖，血管的数量，和胶原蛋白的合成水平。Aftamed诱导的自由基清除酶活性的增加，并显着降低了脂质过氧化水平的伤口中的MDA水平的减少所测量的。结论.这项研究表明，Aftamed凝胶能够显着加速糖尿病大鼠伤口愈合的过程。
Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimeter-diameter full-thickness skin excision wounds were created. Animals were topically treated twice daily. Groups 1, the diabetic control group, were treated with 0.2 mL of sterile distilled water. Group 2 served as a reference standard were treated with 0.2 mL of Intrasite gel. Groups 3 and 4 were treated with 0.2 mL of Aftamed and 0.2 mL of chlorine dioxide gels respectively. Granulation tissue was excised on the 10th day and processed for histological and biochemical analysis. The glutathione peroxidase ,superoxide dismutase activities and the malondialdehyde (MDA) levels were determined. Results. Aftamed-treated wounds exhibited significant increases in hydroxyproline, cellular proliferation, the number of blood vessels, and the level of collagen synthesis. Aftamed induced an increase in the free radical-scavenging enzyme activity and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in the MDA level. Conclusions. This study showed that Aftamed gel is able to significantly accelerate the process of wound healing in diabetic rats.
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DOI：
10.1083/jcb.100.4.1219
发表时间：
1985-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Davidson JM;Klagsbrun M;Hill KE;Buckley A;Sullivan R;Brewer PS;Woodward SC
通讯作者：
Woodward SC
影响因子：
5
作者：
LEDWOZYW, A;MICHALAK, J;KADZIOLKA, A
通讯作者：
KADZIOLKA, A
DOI：
10.1016/0006-291x(76)90747-6
发表时间：
1976-01-01
影响因子：
3.1
作者：
LAWRENCE, RA;BURK, RF
通讯作者：
BURK, RF
影响因子：
3.1
作者：
Buemi, M;Galeano, M;Frisina, N
通讯作者：
Frisina, N
影响因子：
2.6
作者：
Gosain, A;Luisa, MD;DiPietro, A
通讯作者：
DiPietro, A