Ambient air pollution and semen quality.
Ambient air pollution and semen quality.
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DOI：
10.1016/j.envres.2018.02.004
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发表时间：
2018-05
影响因子：
8.3
通讯作者：
Mendola P
中科院分区：
文献类型：
--
作者：
Nobles CJ;Schisterman EF;Ha S;Kim K;Mumford SL;Buck Louis GM;Chen Z;Liu D;Sherman S;Mendola P
环境空气污染与氧化应激的系统性增加有关，精子对氧化应激特别敏感。虽然精液质量下降是生殖能力受损的一个关键机制，但先前的研究还没有建立起空气污染和精液质量之间的明确联系。为了解决这个问题，我们评估了中度空气污染暴露的男性中环境空气污染和精液质量之间的关联。在LIFE研究的501对夫妇中，467名男性伴侣提供了一个或多个精液样本。平均住宅暴露于标准的空气污染物和细颗粒物成分在射精前72天使用修改后的社区多尺度空气质量模型估计。广义估计方程模型估计空气污染物和精液质量参数（体积，计数，低渗肿胀百分比，活力，精子头部，形态和精子染色质参数）之间的关联。模型调整了年龄，体重指数，吸烟和季节。大多数空气污染物和精液参数之间的关联很小。然而，观察到≤2.5 μ m的细颗粒四分位数增加与精子头部尺寸减小相关，包括面积为-0.22（95%CI-0.34，-0.11）µm2，长度为-0.06（95%CI-0.09，-0.03）µm，周长为-0.09（95%CI-0.19，-0.06）µm。细颗粒也与1.03（95%CI 0.40，1.66）更高百分比的精子头与顶体相关。除精子头部参数外，空气污染暴露与精液质量无关。中等水平的环境空气污染可能不是精液质量的主要因素。
Ambient air pollution is associated with systemic increases in oxidative stress, to which sperm are particularly sensitive. Although decrements in semen quality represent a key mechanism for impaired fecundability, prior research has not established a clear association between air pollution and semen quality. To address this, we evaluated the association between ambient air pollution and semen quality among men with moderate air pollution exposure. Of 501 couples in the LIFE study, 467 male partners provided one or more semen samples. Average residential exposure to criteria air pollutants and fine particle constituents in the 72 days before ejaculation was estimated using modified Community Multiscale Air Quality models. Generalized estimating equation models estimated the association between air pollutants and semen quality parameters (volume, count, percent hypo-osmotic swollen, motility, sperm head, morphology and sperm chromatin parameters). Models adjusted for age, body mass index, smoking and season. Most associations between air pollutants and semen parameters were small. However, associations were observed for an interquartile increase in fine particulates ≤2.5 microns and decreased sperm head size, including −0.22 (95% CI −0.34, −0.11) µm2 for area, −0.06 (95% CI −0.09, −0.03) µm for length and −0.09 (95% CI −0.19, −0.06) µm for perimeter. Fine particulates were also associated with 1.03 (95% CI 0.40, 1.66) greater percent sperm head with acrosome. Air pollution exposure was not associated with semen quality, except for sperm head parameters. Moderate levels of ambient air pollution may not be a major contributor to semen quality.
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DOI：
10.1136/heartjnl-2014-306379
发表时间：
2015-02
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Chin MT
通讯作者：
Chin MT
影响因子：
6.7
作者：
Hammoud, Ahmad;Carrell, Douglass T.;Peterson, C. Matthew
通讯作者：
Peterson, C. Matthew
影响因子：
10.4
作者：
Hansen C;Luben TJ;Sacks JD;Olshan A;Jeffay S;Strader L;Perreault SD
通讯作者：
Perreault SD
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.4
作者：
Guven, A.;Kayikci, A.;Cam, M.
通讯作者：
Cam, M.