The effect of ambient air pollution on sperm quality.
The effect of ambient air pollution on sperm quality.
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DOI：
10.1289/ehp.0901022
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发表时间：
2010-02
影响因子：
10.4
通讯作者：
Perreault SD
中科院分区：
文献类型：
--
作者：
Hansen C;Luben TJ;Sacks JD;Olshan A;Jeffay S;Strader L;Perreault SD
研究表明，这与环境空气污染和精子质量有关。我们研究了暴露于臭氧 (O3) 和空气动力学直径 < 2.5 μm 的颗粒物 (PM2.5) 对精子质量的影响。我们重新审视了之前一项关于水消毒副产物的队列研究，以评估 228 名具有不同空气污染状况的假定具有生育能力的男性的精子质量。结果包括精子浓度、每次射精的精子总数（计数）、形态、以及 DNA 完整性和染色质成熟度。在采样前的 90 天内评估了 O3 和 PM2.5 的暴露情况。我们使用多变量线性回归，其中包括不同程度的调整（即，没有或有季节和温度）来评估精子发育关键时期接触空气污染物与不良精子结果之间的关系。精子浓度和数量与 PM2.5 暴露无关，但有证据表明与 O3 浓度以及精子浓度和数量下降存在关联（但无统计学意义）。此外，胞质下降的精子细胞百分比显着增加[β = 2.64； 95% 置信区间 (CI)，0.21–5.06] 和异常头部（β = 0.47；95% CI，0.03–0.92）与基础模型中的 PM2.5 浓度相关。然而，在控制季节和温度后，这些关联以及所有其他精子结果与这两种污染物均没有显着相关。总体而言，尽管我们发现了保护作用和不利作用，但随着 O3 或 PM2.5 暴露的增加，异常精子质量的增加通常没有一致的模式。在这组生育能力男性中，暴露于低于当前国家环境空气质量标准水平的 O3 或 PM2.5 与精子结果的统计显着下降无关。然而，一些结果表明对精子浓度、计数和形态有影响。
Research has suggested an association with ambient air pollution and sperm quality. We investigated the effect of exposure to ozone (O3) and particulate matter < 2.5 μm in aerodynamic diameter (PM2.5) on sperm quality. We reexamined a previous cohort study of water disinfection by-products to evaluate sperm quality in 228 presumed fertile men with different air pollution profiles. Outcomes included sperm concentration, total sperm per ejaculate (count), and morphology, as well as DNA integrity and chromatin maturity. Exposures to O3 and PM2.5 were evaluated for the 90–day period before sampling. We used multivariable linear regression, which included different levels of adjustment (i.e., without and with season and temperature) to assess the relationship between exposure to air pollutants during key periods of sperm development and adverse sperm outcomes. Sperm concentration and count were not associated with exposure to PM2.5, but there was evidence of an association (but not statistically significant) with O3 concentration and decreased sperm concentration and count. Additionally, a significant increase in the percentage of sperm cells with cytoplasmic drop [β = 2.64; 95% confidence interval (CI), 0.21–5.06] and abnormal head (β = 0.47; 95% CI, 0.03–0.92) was associated with PM2.5 concentration in the base model. However, these associations, along with all other sperm outcomes, were not significantly associated with either pollutant after controlling for season and temperature. Overall, although we found both protective and adverse effects, there was generally no consistent pattern of increased abnormal sperm quality with elevated exposure to O3 or PM2.5. Exposures to O3 or PM2.5 at levels below the current National Ambient Air Quality Standards were not associated with statistically significant decrements in sperm outcomes in this cohort of fertile men. However, some results suggested effects on sperm concentration, count, and morphology.
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影响因子：
6.7
作者：
Hammoud, Ahmad;Carrell, Douglass T.;Peterson, C. Matthew
通讯作者：
Peterson, C. Matthew
DOI：
10.1007/s00420-005-0066-3
发表时间：
2006-05-01
影响因子：
3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
6.1
作者：
Rubes, J;Selevan, SG;Perreault, SD
通讯作者：
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影响因子：
2.4
作者：
Guven, A.;Kayikci, A.;Cam, M.
通讯作者：
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