Physiology of endothelin and the kidney.
Physiology of endothelin and the kidney.
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DOI：
10.1002/cphy.c100039
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发表时间：
2011-04
影响因子：
5.8
通讯作者：
Pollock DM
中科院分区：
文献类型：
--
作者：
Kohan DE;Inscho EW;Wesson D;Pollock DM
自1988年发现内皮素（ET）作为一种内皮细胞衍生的肽发挥任何已知的内源性化合物中最强的血管收缩作用以来，内皮素（ET）已成为肾脏生理学和病理生理学的重要调节剂。本文综述了ET系统如何影响健康肾功能;很明显，ET调节肾功能的多个方面。这些包括调节肾小球滤过率和肾血流量，控制肾素释放，以及调节钠、水、质子和碳酸氢盐的转运。这些作用通过ET与肾脏中几乎每种细胞类型的相互作用来发挥，包括系膜细胞、足细胞、内皮细胞、血管平滑肌、肾单位的每一部分和肾神经。此外，虽然不是本综述的主题，但ET也可通过调节肾外系统（包括血管系统、神经系统、肾上腺、循环激素和心脏）间接影响肾功能。如将变得明显的，ET的这些多效性作用在健康的肾功能控制中具有基本的生理重要性。此外，为了帮助正确看待这些影响，我们还将讨论ET系统的改变如何导致高血压和肾脏疾病，尽管程度相对有限。
Since its discovery in 1988 as an endothelial cell-derived peptide that exerts the most potent vasoconstriction of any known endogenous compound, endothelin (ET) has emerged as an important regulator of renal physiology and pathophysiology. This review focuses on how the ET system impacts renal function in health; it is apparent that ET regulates multiple aspects of kidney function. These include modulation of glomerular filtration rate and renal blood flow, control of renin release, and regulation of transport of sodium, water, protons and bicarbonate. These effects are exerted through ET interactions with almost every cell type in the kidney, including mesangial cells, podocytes, endothelium, vascular smooth muscle, every section of the nephron, and renal nerves. In addition, while not the subject of the current review, ET can also indirectly affect renal function through modulation of extrarenal systems, including the vasculature, nervous system, adrenal gland, circulating hormones and the heart. As will become apparent, these pleiotropic effects of ET are of fundamental physiologic importance in the control of renal function in health. In addition, to help put these effects into perspective, we will also discuss, albeit to a relatively limited extent, how alterations in the ET system can contribute to hypertension and kidney disease.
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影响因子：
3
作者：
AKABANE, S;YOSHIMI, H;OMAE, T
通讯作者：
OMAE, T
DOI：
10.1152/ajpheart.2001.281.5.h2218
发表时间：
2001-11-01
影响因子：
4.8
作者：
Ballew, JR;Fink, GD
通讯作者：
Fink, GD
影响因子：
--
作者：
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通讯作者：
REMUZZI, G
影响因子：
15.9
作者：
Ahn, D;Ge, YQ;Kohan, DE
通讯作者：
Kohan, DE
DOI：
10.1152/ajpregu.1998.275.6.r1833
发表时间：
1998-12-01
影响因子：
2.8
作者：
Andersen, LJ;Norsk, P;Bie, P
通讯作者：
Bie, P