Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels.
Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels.
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DOI：
10.1289/ehp.11379
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发表时间：
2008-10
影响因子：
10.4
通讯作者：
Goldman LR
中科院分区：
文献类型：
--
作者：
Herbstman JB;Sjödin A;Apelberg BJ;Witter FR;Halden RU;Patterson DG;Panny SR;Needham LL;Goldman LR
发育中的婴儿可能对多氯联苯(PCbs)和多溴联苯醚(PBDEs)等化学品造成的激素干扰特别敏感。我们研究了脐血多氯联苯和多溴二苯醚水平与脐血血清和新生儿血点中甲状腺激素的关系。我们检测了2004年至2005年在约翰霍普金斯医院分娩的297名新生儿脐带血中的多氯联苯和多溴二苯醚、促甲状腺激素(TSH)、甲状腺素(T4)和游离T4(FT4)。我们提取了在医院采集的血点和新生儿访视时测量的总T4(TT4)的结果。我们使用分娩方式(加强阴道分娩和非选择性剖宫产)作为分娩期间应激的替代品，众所周知，分娩应激会改变脐带血甲状腺激素。在整个研究人群中，没有化合物与平均TSH、FT4或TT4的变化有关。BDE-100与低脐带TT4的几率增加相关，BDE-153与低脐带TT4和FT4的几率增加相关，而没有化合物与高TSH的几率增加相关。对于自然分娩、阴道分娩、无辅助分娩的婴儿，多氯联苯与脐血TT4和FT4降低以及新生儿血点TT4降低有关。多溴二苯醚与TT4和FT4的测量显示出一致但主要不显著的负相关。出生前接触多氯联苯和多溴二苯醚与自然、无辅助阴道分娩的婴儿的TT4和FT4水平降低有关。与分娩方式相关的产中应激可能会掩盖多氯联苯和多溴二苯醚的激素影响。
Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). We investigated relationships between cord serum levels of PCBs and PBDEs and thyroid hormones measured in cord blood serum and neonatal blood spots. We measured PCBs and PBDEs, thyrotropin (TSH), thyroxine (T4) and free T4 (FT4) in cord blood serum from 297 infants who were delivered at the Johns Hopkins Hospital in 2004–2005. We abstracted results of total T4 (TT4) measured in blood spots collected in the hospital and at neonatal visits. We used delivery mode (augmented vaginal deliveries and nonelective cesarean deliveries) as a surrogate for intrapartum stress, which is known to alter cord blood thyroid hormones. In the full study population, no compounds were associated with a change in average TSH, FT4, or TT4. BDE-100 was associated with increased odds of low cord TT4, BDE-153 with increased odds of low cord TT4 and FT4, and no compounds were associated with increased odds of high TSH. For infants born by spontaneous, vaginal, unassisted deliveries, PCBs were associated with lower cord TT4 and FT4 and lower TT4 measured in neonatal blood spots. PBDEs showed consistent but mainly nonsignificant negative associations with TT4 and FT4 measurements. Prenatal PCB and PBDE exposures were associated with reduced TT4 and FT4 levels among infants born by spontaneous, unassisted vaginal delivery. Intrapartum stress associated with delivery mode may mask hormonal effects of PCBs and PBDEs.
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影响因子：
8.8
作者：
Darnerud, Per Ola;Aune, Marie;Hallgren, Sara
通讯作者：
Hallgren, Sara
DOI：
10.1016/s0301-2115(01)00298-6
发表时间：
2001-09-01
影响因子：
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作者：
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Hagmar, L
通讯作者：
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影响因子：
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作者：
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通讯作者：
Schepens, R
影响因子：
2.5
作者：
Bernert, JT;McGuffey, JE;Pirkle, JL
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Pirkle, JL