Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing.
Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing.
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DOI：
10.1590/0104-1169.3143.2385
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发表时间：
2014-01
影响因子：
1.8
通讯作者：
Bastos ML
中科院分区：
文献类型：
--
作者：
Sarmento Pde A;Ataíde Tda R;Barbosa AP;Araújo-Júnior JX;Lúcio IM;Bastos ML
目的：研究中药甘草茎乙醇提取物的抗菌活性、细胞毒活性和愈合活性。结核病通过局部使用和/或口服摄入。使用纸片扩散法的体外抗微生物测定、卤虫毒性试验和Wistar大鼠的体内测定。从这些收集的临床，组织学和生物化学数据，用于评估愈合过程。体外抗微生物试验显示出对化脓性链球菌、金黄色葡萄球菌和表皮葡萄球菌的活性，抑制区分别为18、14和10 mm。最低抑菌浓度为62.5 μg/ml。金黄色葡萄球菌，该细菌被选择用于体外测定。用含Z.结核病在减小伤口直径方面表现出最好的结果，组织学样品中存在上皮再形成证实了这一数据。该提取物被证明有希望用于继续研究，该研究可以鉴定负责药理学活性的活性成分及其在伤口愈合过程中的作用机制，从而开发可以用作修复感染的皮肤伤口的替代手段的产品。
to evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion. antimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process. in vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples. the extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.
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DOI：
10.1590/1808-1657v77p4412010
发表时间：
2010-09-01
期刊：
Arquivos do Instituto Biológico
影响因子：
--
作者：
Batista, J.S.;Silva, A.E.;Olinda, R.G.
通讯作者：
Olinda, R.G.
影响因子：
1.1
作者：
Lucena, Periguari Luiz Holanda de;Ribas Filho, Jurandir Marcondes;Thiele, Edilson Schwansee
通讯作者：
Thiele, Edilson Schwansee
影响因子：
1.7
作者：
Mendonça, Ricardo José de;Coutinho-Netto, Joaquim
通讯作者：
Coutinho-Netto, Joaquim
影响因子：
5.7
作者：
Bastos, Maria Lysete A.;Lima, Maria Raquel F.;Lemos, Rosangela P. L.
通讯作者：
Lemos, Rosangela P. L.
影响因子：
1.8
作者：
Alvim, Neide Aparecida Titonelli;Ferreira, Márcia de Assunção;Almeida Filho, Antonio José de
通讯作者：
Almeida Filho, Antonio José de