Trabecular bone score and its association with Cobb angle kyphosis in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) Study.
Trabecular bone score and its association with Cobb angle kyphosis in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) Study.
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DOI：
10.1007/s00198-021-06267-w
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发表时间：
2022-05
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虽然椎体骨折和低骨密度（BMD）有助于脊柱后凸的进展，但尚不清楚骨小梁评分（TBS）是否可以提供影响脊柱后凸程度的骨质量的额外信息。我们假设退化的TBS可能与高后凸（HK）相关，定义为Cobb角bbb50°。使用来自1997名男性骨质疏松性骨折（mro）研究参与者的数据，他们测量了基线TBS和Cobb角后凸，我们调查了退化TBS的男性是否更容易出现后凸过度，即使在调整了骨密度和普遍的椎体骨折之后。男性平均年龄为74±6（平均±SD）岁，平均后凸角为38.6±11.5°，295例（15%）为重度后凸，416例（21%）为退化性TBS。在调整年龄、临床、种族、BMI、髋部骨密度和椎骨骨折发生率后，与TBS患者相比，TBS退化患者更容易发生HK （OR: 1.47, 95% CI: 1.06-2.06, p = 0.02）。如果模型中纳入脊柱而非髋关节骨密度，优势比降至1.35 （95% CI: 0.97-1.89, p = 0.08）。TBS退化的老年男性更有可能发生不能由潜在椎体骨折解释的HK。脊柱后凸症（HK），或脊柱前弯加重，通常影响老年人，尽管其原因尚不完全清楚。我们对1997名老年男性进行了骨质量测量，即骨小梁评分（TBS）是否与HK有关的测试，并确定TBS退化的男性更有可能患有HK。
While vertebral fractures and low bone mineral density (BMD) contribute to kyphosis progression, it is unknown whether the trabecular bone score (TBS) may provide additional information on bone quality that could influence the degree of kyphosis. We hypothesized that degraded TBS would be associated with hyperkyphosis (HK) defined as a Cobb angle > 50°. Using data from 1,997 participants of the Osteoporotic Fractures in Men (MrOS) study who had baseline TBS and Cobb angle kyphosis measured, we investigated whether men with degraded TBS were more likely to be hyperkyphotic, even after adjustment for BMD and prevalent vertebral fractures. Men were an average age of 74 ± 6 (mean ± SD) years with a mean kyphosis angle of 38.6 ± 11.5°, 295 (15%) were classified as hyperkyphotic, and 416 (21%) had degraded TBS. Compared with men with TBS > 1.2, men with degraded TBS were more likely to have HK (OR: 1.47, 95% CI: 1.06–2.06, p = 0.02) after adjusting for age, clinic, race, BMI, hip BMD and prevalent vertebral fracture. If spine instead of hip BMD was included in the model, the odds ratio decreased to 1.35 (95% CI: 0.97–1.89, p = 0.08). Older men with degraded TBS are more likely to have HK not explained by underlying vertebral fractures. Hyperkyphosis (HK), or accentuated forward spinal curvature, commonly affects older people, although its causes are not completely understood. We tested whether a measure of bone quality, trabecular bone score (TBS), is associated with HK in 1,997 older men, and determined that men with degraded TBS were more likely to have HK.
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影响因子：
4.1
作者：
Briot, Karine;Paternotte, Simon;Roux, Christian
通讯作者：
Roux, Christian
影响因子：
4.1
作者：
Pothuaud, Laurent;Carceller, Pascal;Hans, Didier
通讯作者：
Hans, Didier
影响因子：
2.5
作者：
Winzenrieth, Renaud;Michelet, Franck;Hans, Didier
通讯作者：
Hans, Didier
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
影响因子：
6.2
作者：
Schousboe, John T.;Vo, Tien;Ensrud, Kristine E.
通讯作者：
Ensrud, Kristine E.