Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity.
Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity.
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DOI：
10.1016/j.jpsychires.2021.08.012
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发表时间：
2021-10
影响因子：
4.8
通讯作者：
Neylan TC
中科院分区：
文献类型：
--
作者：
Young DA;Chao LL;Zhang H;Metzler T;Ross J;Richards A;O'Donovan A;Inslicht SS;Neylan TC
虽然 BDNF Val66Met 多态性与各种创伤和焦虑相关的精神疾病有关，但人们对可能调节其与威胁敏感性客观测量之间关系的神经结构的关注有限。因此，我们评估了 Val66Met 多态性与先前与焦虑和 PTSD 相关的大脑区域体积是否存在相互作用，例如腹内侧前额叶皮层 (vmPFC)、岛叶皮层 (IC) 以及背侧和腹侧前扣带皮层 (dACC 和 vACC)，以预测退伍军人临床样本中恐惧增强的心理生理反应。 110 名参与者参与了增强恐惧的声音惊吓范式，并提供了遗传和成像数据。恐惧条件包括无、模糊和高度威胁条件（休克）。心理生理反应测量包括肌电图（EMG）、皮肤电导反应（SCR）和心率（HR）。还评估了 PTSD 状态、创伤史和人口统计数据。 Met 等位基因携带者状态与预测 SCR 的 vmPFC、IC、dACC 和 vACC 体积存在交互作用（所有区域 p < 0.001）。然而，只有 vmPFC 和 IC 显着调节 Val66Met 和心理生理反应 (SCR) 之间的关系。 Val66met 多态性可能通过与减少的 vmPFC 和 IC 体积相互作用而增加对 PTSD 和焦虑症的易感性。未来的研究应该检验这些关系是否可能与纵向的不同病程或对治疗的反应有关。
While the BDNF Val66Met polymorphism has been linked to various trauma and anxiety – related psychiatric disorders, limited focus has been on the neural structures that might modulate its relationship with objective measures of threat sensitivity. Therefore, we assessed whether there was an interaction of Val66Met polymorphism with brain area volumes previously associated with anxiety and PTSD, such as the ventromedial prefrontal cortex (vmPFC), insular cortex (IC), and dorsal and ventral anterior cingulate cortices (dACC and vACC), in predicting fear-potentiated psychophysiological response in a clinical sample of Veterans. 110 participants engaged in a fear-potentiated acoustic startle paradigm and provided genetic and imaging data. Fear conditions included no, ambiguous, and high threat conditions (shock). Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate (HR). PTSD status, trauma history, and demographics were also assessed. There was an interaction of Met allele carrier status with vmPFC, IC, dACC, and vACC volumes for predicting SCR (p < 0.001 for all regions). However, only vmPFC and IC significantly moderated the relationship between Val66Met and psychophysiological response (SCR). The Val66met polymorphism may increase susceptibility to PTSD and anxiety disorders via an interaction with reduced vmPFC and IC volume. Future research should examine whether these relationships might be associated with a differential course of illness longitudinally or response to treatments.
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DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
DOI：
10.1111/j.1601-183x.2012.00801.x
发表时间：
2012-07
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Andero R;Ressler KJ
通讯作者：
Ressler KJ
影响因子：
6.4
作者：
Marusak HA;Kuruvadi N;Vila AM;Shattuck DW;Joshi SH;Joshi AA;Jella PK;Thomason ME
通讯作者：
Thomason ME
影响因子：
5.3
作者：
Liu, IYC;Lyons, WE;Thompson, RF
通讯作者：
Thompson, RF
影响因子：
17.7
作者：
Kilpatrick, Dean G.;Koenen, Karestan C.;Gelernter, Joel
通讯作者：
Gelernter, Joel