Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis.
Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis.
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DOI：
10.3389/fendo.2020.548812
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发表时间：
2020
影响因子：
5.2
通讯作者：
Tao L
中科院分区：
文献类型：
--
作者：
Tao Z;Wang J;Wen K;Yao R;Da W;Zhou S;Meng Y;Qiu S;Yang K;Zhu Y;Tao L
骨质疏松症已经成为一种世界性疾病，其特征是骨密度降低和骨结构改变，导致脆性骨折的风险增加。越来越多的研究表明，在骨质疏松症中，成骨细胞经历了多种不同原因的大量程序性死亡事件，并释放NLRP3和白细胞介素2(如炎症因子)，它们在导致破骨细胞过度分化和导致过度骨吸收中起着关键作用。NLRP3在下垂过程中被激活，将IL-1β和IL-18的前体分子加工成成熟的形式，并伴随着细胞破裂释放到细胞外环境中。所有这些化合物都是导致上睑下垂的经典因素。在骨质疏松症中，通常可以观察到上睑下垂的细胞效应。虽然以前的许多研究都集中在这些炎症因子在骨质疏松中的发病机制上，但以前还没有对上睑下垂进行评估。本文首次提出了骨质疏松症发病机制的新假说，为今后治疗骨质疏松症提供了新的方向。
Osteoporosis has become a worldwide disease characterized by a reduction in bone mineral density and the alteration of bone architecture leading to an increased risk of fragility fractures. And an increasing number of studies have indicated that osteoblasts undergo a large number of programmed death events by many different causes in osteoporosis and release NLRP3 and interleukin (e.g., inflammatory factors), which play pivotal roles in contributing to excessive differentiation of osteoclasts and result in exaggerated bone resorption. NLRP3 is activated during pyroptosis and processes the precursors of IL-1β and IL-18 into mature forms, which are released into the extracellular milieu accompanied by cell rupture. All of these compounds are the classical factors of pyroptosis. The cellular effects of pyroptosis are commonly observed in osteoporosis. Although many previous studies have focused on the pathogenesis of these inflammatory factors in osteoporosis, pyroptosis has not been previously evaluated. In this review, pyroptosis is proposed as a novel hypothesis of osteoporosis pathogenesis for the first time, thus providing a new direction for the treatment of osteoporosis in the future.
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影响因子：
1.7
作者：
Banerjee, Dibyendu;Chakraborty, Baishali;Chakraborty, Banya
通讯作者：
Chakraborty, Banya
影响因子：
--
作者：
Elshaier, Arriel M.;Hakimiyan, Arnavaz A.;Rappoport, Lev;Rueger, David C.;Chubinskaya, Susan
通讯作者：
Chubinskaya, Susan
影响因子：
3.1
作者：
Baker, PJ;Dixon, M;Roopenian, DC
通讯作者：
Roopenian, DC
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
4.4
作者：
Cheung, H;Chen, NJ;Yeh, WC
通讯作者：
Yeh, WC