Preliminary Evidence for the Impact of Combat Experiences on Gray Matter Volume of the Posterior Insula.
Preliminary Evidence for the Impact of Combat Experiences on Gray Matter Volume of the Posterior Insula.
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DOI：
10.3389/fpsyg.2017.02151
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发表时间：
2017
影响因子：
3.8
通讯作者：
Aupperle RL
中科院分区：
文献类型：
--
作者：
Clausen AN;Billinger SA;Sisante JV;Suzuki H;Aupperle RL
背景：暴露于战斗中的退伍军人患心血管疾病的风险增加。前扣带皮层（ACC）和脑岛参与了对情绪压力源和体内平衡过程的自主觉醒，这可能导致退伍军人的心血管功能障碍。本研究旨在探讨战斗经验、吻侧前扣带区和脑岛后部容积与退伍军人心血管健康之间的交叉关系。方法：对24名男性退伍军人的战斗经历和创伤后应激症状进行临床评估。受试者完成磁共振成像扫描，并使用FreeSurfer进行自动分割，以估计吻侧ACC和后岛的区域灰质体积（控制总灰质体积）。血流介导扩张（FMD）评估心血管健康。使用他们的il-sen稳健回归和Welch方差分析来检验战斗经历和PTSD症状与(1)FMD和(2)区域灰质体积的关系。结果：增加的战斗经验，部署时间和多次部署与较小的后岛体积有关。战斗经历与较差的心血管健康状况有轻微关联。然而，心血管健康与吻侧ACC或脑岛后部容积无关。结论：本研究为战斗经验、部署时间和多次部署与后岛体积较小的关系提供了初步证据。结果可能表明，战斗经验增加的退伍军人可能表现出更多的调节自主神经系统的功能障碍，这是后岛的一个关键功能。然而，战斗和心血管健康之间的关系并不是由区域脑容量介导的。未来的研究有必要进一步阐明战斗退伍军人后岛体积变小对心血管或功能的影响。
Background: Combat-exposed veteran populations are at an increased risk for developing cardiovascular disease. The anterior cingulate cortex (ACC) and insula have been implicated in both autonomic arousal to emotional stressors and homeostatic processes, which may contribute to cardiovascular dysfunction in combat veteran populations. The aim of the present study was to explore the intersecting relationships of combat experiences, rostral ACC and posterior insula volume, and cardiovascular health in a sample of combat veterans. Method: Twenty-four male combat veterans completed clinical assessment of combat experiences and posttraumatic stress symptoms. Subjects completed a magnetic resonance imaging scan and autosegmentation using FreeSurfer was used to estimate regional gray matter volume (controlling for total gray matter volume) of the rostral ACC and posterior insula. Flow-mediated dilation (FMD) was conducted to assess cardiovascular health. Theil-sen robust regressions and Welch's analysis of variance were used to examine relationships of combat experiences and PTSD symptomology with (1) FMD and (2) regional gray matter volume. Results: Increased combat experiences, deployment duration, and multiple deployments were related to smaller posterior insula volume. Combat experiences were marginally associated with poorer cardiovascular health. However, cardiovascular health was not related to rostral ACC or posterior insula volume. Conclusion: The present study provides initial evidence for the relationships of combat experiences, deployment duration, and multiple deployments with smaller posterior insula volume. Results may suggest that veterans with increased combat experiences may exhibit more dysfunction regulating the autonomic nervous system, a key function of the posterior insula. However, the relationship between combat and cardiovascular health was not mediated by regional brain volume. Future research is warranted to further clarify the cardiovascular or functional impact of smaller posterior insula volume in combat veterans.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.7
作者：
Aupperle RL;Melrose AJ;Stein MB;Paulus MP
通讯作者：
Paulus MP
影响因子：
3.3
作者：
Buckley, TC;Holohan, D;Suvak, M
通讯作者：
Suvak, M
DOI：
10.1111/j.1749-6632.2010.05445.x
发表时间：
2010-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2010
影响因子：
--
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ