Sleep Promotes, and Sleep Loss Inhibits, Selective Changes in Firing Rate, Response Properties and Functional Connectivity of Primary Visual Cortex Neurons.
Sleep Promotes, and Sleep Loss Inhibits, Selective Changes in Firing Rate, Response Properties and Functional Connectivity of Primary Visual Cortex Neurons.
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DOI：
10.3389/fnsys.2018.00040
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发表时间：
2018
影响因子：
3
通讯作者：
Aton SJ
中科院分区：
文献类型：
--
作者：
Clawson BC;Durkin J;Suresh AK;Pickup EJ;Broussard CG;Aton SJ
最近的研究表明，睡眠差异改变皮层神经元的活动基于放电率在之前的觉醒-增加稀疏放电神经元的放电率和降低那些快速放电神经元。因为稀疏放电的皮层神经元可能在感觉处理中发挥专门的作用，睡眠可以通过对稀疏放电神经元的选择性作用来促进感觉功能。为了验证这一假设，我们分析了初级视觉皮层（V1）神经元在一个新的视觉体验，诱导V1可塑性（或控制经验，不），和一段时间的后续随意睡眠或部分睡眠剥夺的纵向电生理记录。我们发现，在一天的随意睡眠中，自发和视觉诱发的放电率在稀疏放电的V1神经元中选择性地增加。这些稀疏放电的神经元具有更高的视觉反应，并且比它们的高放电率邻居表现出更大的方向选择性。他们也往往是“独奏家”，而不是“合唱团”-显示相对较弱的耦合发射到V1人口活动。这些群体特异性的放电率变化在一天的早期或晚期被睡眠中断所阻断，并且似乎是由快速眼动（REM）睡眠中神经元放电率的增加引起的。在一个模式化的视觉体验，诱导V1的方向选择性反应增强（OSRP），稀疏放电和弱群体耦合神经元显示出最高水平的睡眠依赖性反应可塑性。在一天的随意睡眠中，群体耦合强度选择性地增加了稀疏放电的神经元这种效应也被睡眠剥夺所破坏。总之，这些数据表明，睡眠可以通过增强高度反应性和刺激选择性皮层神经元的功能连接和放电率来优化感觉功能，同时通过减少选择性较低，放电较快的神经元的活动来减少网络中的噪音。
Recent studies suggest that sleep differentially alters the activity of cortical neurons based on firing rates during preceding wake—increasing the firing rates of sparsely firing neurons and decreasing those of faster firing neurons. Because sparsely firing cortical neurons may play a specialized role in sensory processing, sleep could facilitate sensory function via selective actions on sparsely firing neurons. To test this hypothesis, we analyzed longitudinal electrophysiological recordings of primary visual cortex (V1) neurons across a novel visual experience which induces V1 plasticity (or a control experience which does not), and a period of subsequent ad lib sleep or partial sleep deprivation. We find that across a day of ad lib sleep, spontaneous and visually-evoked firing rates are selectively augmented in sparsely firing V1 neurons. These sparsely firing neurons are more highly visually responsive, and show greater orientation selectivity than their high firing rate neighbors. They also tend to be “soloists” instead of “choristers”—showing relatively weak coupling of firing to V1 population activity. These population-specific changes in firing rate are blocked by sleep disruption either early or late in the day, and appear to be brought about by increases in neuronal firing rates across bouts of rapid eye movement (REM) sleep. Following a patterned visual experience that induces orientation-selective response potentiation (OSRP) in V1, sparsely firing and weakly population-coupled neurons show the highest level of sleep-dependent response plasticity. Across a day of ad lib sleep, population coupling strength increases selectively for sparsely firing neurons—this effect is also disrupted by sleep deprivation. Together, these data suggest that sleep may optimize sensory function by augmenting the functional connectivity and firing rate of highly responsive and stimulus-selective cortical neurons, while simultaneously reducing noise in the network by decreasing the activity of less selective, faster-firing neurons.
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影响因子：
5.3
作者：
Batterink, Laura J.;Creery, Jessica D.;Paller, Ken A.
通讯作者：
Paller, Ken A.
DOI：
10.1073/pnas.1208093110
发表时间：
2013-02-19
影响因子：
11.1
作者：
Aton, Sara J.;Broussard, Christopher;Frank, Marcos G.
通讯作者：
Frank, Marcos G.
影响因子：
2
作者：
Ribeiro, S;Goyal, V;Pavlides, C
通讯作者：
Pavlides, C
影响因子：
2.7
作者：
Delorme JE;Kodoth V;Aton SJ
通讯作者：
Aton SJ
影响因子：
16.2
作者：
Chauvette S;Seigneur J;Timofeev I
通讯作者：
Timofeev I