Regional and remote connectivity patterns in focal extratemporal lobe epilepsy.
Regional and remote connectivity patterns in focal extratemporal lobe epilepsy.
复制标题
局灶性颞外叶癫痫的区域和远程连接模式
DOI：
10.21037/atm-21-1374
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发表时间：
2021-07
影响因子：
--
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Liu W;Yue Q;Gong Q;Zhou D;Wu X
背景 局灶性癫痫占癫痫病例的大多数，而额叶癫痫（FLE）在颞外癫痫综合征的病例中所占比例最大。致癫痫区域通常不易定位，导致缺乏影像学研究。本研究的目的是评估功能连接模式，以探索这种疾病的潜在病理机制。方法 招募 43 例局灶性颞外癫痫患者[平均年龄±标准差（SD）：29.51±8.04 岁，19 名男性]和相同数量的健康对照者（平均年龄±SD：29.56±8.02 岁，19 名男性）进行功能磁共振成像。测量平均区域同质性 (ReHo)，并确定患者 ReHo 发生显着变化的区域，以检查功能连接性 (FC)。特别是对患者默认模式网络 (DMN) 内的 FC 进行了分析。结果 颞叶癫痫患者的双侧中央前回 ReHo 显着高于健康对照，而额小脑区域 ReHo 低于健康对照[P<0.05，高斯随机场 (GRF) 校正]。基于感兴趣区域的 FC 分析显示，额顶叶岛区域的连通性显着较高，而额叶小脑区域的 FC 较低（P<0.05，GRF 校正）。还证明了 DMN 内 FC 的改变（P<0.05，GRF 校正）。结论 基于感兴趣区的ReHo和FC分析表明，颞外叶癫痫中癫痫相关神经网络主要位于额叶区。这些发现揭示了大规模神经网络和额颞叶-小脑区域的相互作用和连接性的破坏，表明基于连接性的病理生理学。
Background Focal epilepsy accounts for most epilepsy cases, and frontal lobe epilepsy (FLE) accounts for the largest proportion of cases of extratemporal epilepsy syndrome. The epileptogenic zone is usually not easy to locate, contributing to a lack of imaging studies. The objective of this study was to evaluate functional connectivity patterns to explore the underlying pathological mechanisms of this disorder. Methods Forty-three patients with focal extratemporal epilepsy [mean age ± standard deviation (SD): 29.51±8.04 years, 19 males] and the same number of healthy controls (mean age ± SD: 29.56±8.02 years, 19 males) were recruited to undergo functional magnetic resonance imaging. Mean regional homogeneity (ReHo) was measured, and regions showing significant alterations in ReHo in patients were identified to examine functional connectivity (FC). In particular, FC within the default mode network (DMN) in patients was analyzed. Results Patients with extratemporal lobe epilepsy showed significantly higher ReHo in the bilateral precentral gyrus, and lower ReHo in frontal-cerebellum regions than healthy controls [P<0.05, Gaussian random field (GRF)-corrected]. FC analysis based on regions of interest showed significantly higher connectivity in the frontoparietal-insula region and lowered FC in the frontal-cerebellum regions (P<0.05, GRF-corrected). Altered FC within DMN was also demonstrated (P<0.05, GRF-corrected). Conclusions Analyses of ReHo and FC based on regions of interest suggest epilepsy-related neural networks are located mainly in frontal regions in extratemporal lobe epilepsy. These findings reveal disruptions of interactions and connectivity of large-scale neural networks and frontotemporal-cerebellar regions, suggesting connectivity-based pathophysiology.
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影响因子：
5.6
作者：
Kay BP;DiFrancesco MW;Privitera MD;Gotman J;Holland SK;Szaflarski JP
通讯作者：
Szaflarski JP
影响因子：
14.5
作者：
Picard, F.;Bruel, D.;Bottlaender, M.
通讯作者：
Bottlaender, M.
影响因子：
29
作者：
Noe, Katherine;Sulc, Vlastimil;Wong-Kisiel, Lily;Wirrell, Elaine;Van Gompel, Jamie J.;Wetjen, Nicholas;Britton, Jeffrey;So, Elson;Cascino, Gregory D.;Marsh, W. Richard;Meyer, Fredric;Horinek, Daniel;Giannini, Caterina;Watson, Robert;Brinkmann, Benjamin H.;Stead, Matt;Worrell, Gregory A.
通讯作者：
Worrell, Gregory A.
影响因子：
5.6
作者：
Englot DJ;Konrad PE;Morgan VL
通讯作者：
Morgan VL
影响因子：
5.6
作者：
Berg, Anne T.;Berkovic, Samuel F.;Scheffer, Ingrid E.
通讯作者：
Scheffer, Ingrid E.