Ultrasound-guided large-core needle biopsies of breast lesions: analysis of 962 cases to determine the number of samples for reliable tumour classification.
Ultrasound-guided large-core needle biopsies of breast lesions: analysis of 962 cases to determine the number of samples for reliable tumour classification.
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DOI：
10.1038/sj.bjc.6602303
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发表时间：
2005-01-31
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
这一机构研究的目的是确定在三维超声(3D-US)验证下，足以获得可靠的超声可检测乳腺病变的组织学诊断的大芯针活检(LCNB)的数量。在28个月的时间里，在3D-US验证下进行了962例超声引导下的LCNB检查，以评估962个乳腺病变。所有活检均使用装有14号针头(22 mm偏移量)的自动核心活检装置进行。收集了962个乳腺病变的活检数据。对659个病变进行了手术随访。超声引导下LCNB诊断乳腺恶性肿瘤的敏感性为98.2%，每个病灶3个病灶。在少数病例中，开放手术标本显示浸润性癌的存在，与最初基于LNCB的分类相反，包括导管原位癌(DCIS，11个病变)、小叶原位癌(1个病变)和不典型导管过度肥大(1个病变)。由于基于乳腺影像和组织学发现的分类不一致，这些肿瘤中的8个随后被切除。在患者要求切除的病变中，尽管LCNB诊断为良性，但仍有两个是浸润性癌，一个是DCIS。我们证明，三个3D-US引导的经皮核心标本足以实现对超声可检测的乳腺病变进行可靠的组织学评估，并允许以高灵敏度和低假阴性率检测恶性肿瘤。
The objective of this one-institutional study was to determine the number of large-core needle biopsies (LCNB), under three-dimensional ultrasound (3D-US) validation, that are sufficient to obtain a reliable histological diagnosis of a sonographically detectable breast lesion. Over an 28-month period, 962 sonographically guided LCNB were performed under 3D-US validation to assess 962 breast lesions. All biopsies were carried out with an automated core biopsy device fitted with 14-gauge (22 mm excursion) needles. Data of 962 biopsied breast lesions were gathered. Surgical follow-up was available for 659 lesions. Breast malignancies were diagnosed by ultrasound-guided LCNB with a sensitivity of 98.2% by performing three cores per lesion. In few cases, the open surgical specimen revealed the presence of invasive carcinomas in contrast to initial LNCB-based classification as ductal carcinomas in situ (DCIS, 11 lesions), lobular carcinoma in situ (one lesion), and atypical ductal hyperpasia (one lesion). Owing to disagreement between classification based on breast-imaging and histological findings, eight of these tumours were subsequently excised. Of the lesions that were removed at the patients’ requests despite benign LCNB diagnosis, two were infiltrating carcinoma and one a DCIS. We demonstrate that three 3D-US-guided percutaneous core specimens are sufficient to achieve tissue for a reliable histological assessment of sonographically detectable breast lesions and allow the detection of malignancies with high sensitivity and low rate of false-negative diagnoses.
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影响因子：
8.8
作者：
Pijnappel, RM;van den Donk, M;Peeters, PHM
通讯作者：
Peeters, PHM
影响因子：
19.7
作者：
Lee, CH;Philpotts, LE;Tocino, I
通讯作者：
Tocino, I
影响因子：
19.7
作者：
PARKER, SH;BURBANK, F;WYNN, RT
通讯作者：
WYNN, RT
影响因子：
7.1
作者：
Weismann, CF;Forstner, R;Rettenbacher, T
通讯作者：
Rettenbacher, T
影响因子：
19.7
作者：
STAVROS, AT;THICKMAN, D;SISNEY, GA
通讯作者：
SISNEY, GA