Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes.
Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes.
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高度近视眼中的视线引起的后眼睛变形的超声评估。
DOI：
10.1167/iovs.64.13.38
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发表时间：
2023-10-03
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
建立患有或不患有后葡萄肿的高度近视眼在不同注视方向上后眼壁变形性的定量指标。对 53 名高度近视患者（106 只眼睛）进行了一项前瞻性研究。超声扫描主要包括向上、向下、鼻部和颞部凝视。使用经过验证的基于强度的分割算法来量化数字化 B 扫描图像上的后眼壁几何形状。计算后眼壁局部曲率 (K) 和到传感器的距离 (L)。评估了注视方向、眼轴长度 (AL) 以及葡萄肿的存在与 K 和 L 参数之间的关联。共有 53 名参与者（106 只眼睛）接受了研究。多元回归分析表明，考虑到较长的 AL 和葡萄肿的存在后，偏心注视通常与各种 K 和 L 参数独立相关。具体而言，向下凝视与眼壁后凹度增加相关，如 K 最大值 (KMax)（β = 0.050，P < 0.001）和 KMax 绝对值（β = 0.041，P = 0.011）所反映。向下凝视和向上凝视均与绝对 KMax（与更明显、更陡峭的葡萄肿脊线一致）、局部 KMax（以较小间隔检测 KMax）和 Kstd（代表葡萄肿存在的可能性）导数的增加以及最大 L（代表葡萄肿顶点的移动）的减少独立相关，所有 P < 0.05。与向上凝视的β系数相比，向下凝视的β系数始终更大。考虑到 AL 和葡萄肿的存在后，水平注视仅与 L 标准差（也代表葡萄肿存在的可能性）和 L 最大值的减小独立相关。考虑到 AL 和葡萄肿的存在后，向下注视会导致高度近视眼后眼壁凹度显着增加。与向下凝视相比，向上凝视导致葡萄肿脊陡度和葡萄肿存在可能性的幅度较小，但发生显着变化。水平凝视似乎与较少的后眼壁几何参数相关。需要研究进一步评估近距离工作时向下凝视对后眼壁凹度的影响与对近视发展和进展的可能影响之间的关联。
To establish a quantitative metric of posterior eyewall deformability in different directions of gaze in highly myopic eyes with and without posterior staphyloma. A prospective study was performed on 53 highly myopic patients (106 eyes). Ultrasound scans were acquired in primary, up, downward, nasal, and temporal gazes. A validated intensity-based segmentation algorithm was used to quantify the posterior eyewall geometry on digitalized B-scan images. Posterior eyewall local curvature (K) and distance (L) to the transducer were calculated. The associations between directions of gaze, axial length (AL), and presence of staphyloma with the K and L parameters were assessed. A total of 53 participants (106 eyes) were studied. Multivariate regression analysis demonstrated that, after accounting for longer AL, and presence of staphyloma, eccentric gaze was often independently associated with various K and L parameters. Specifically, downward gaze was associated with increased posterior eyewall concavity as reflected in the maximum of K (KMax) (β = 0.050, P < 0.001) and absolute value of KMax (β = 0.041, P = 0.011). Both downward gaze and upgaze were independently associated with increase in the derivative of absolute KMax (which is consistent with more apparent, steeper staphyloma ridges), local KMax (which detects KMax at smaller intervals), and Kstd (which represents likelihood of staphyloma presence) and decrease in maximum of L (which represents movement of the staphyloma apex) with all P < 0.05. The β coefficients for downward gaze were consistently greater in magnitude compared with those in upgaze. After accounting for AL and presence of staphyloma, horizontal gazes were independently associated only with decrease in the standard deviation of L (which also represents likelihood of staphyloma presence) and maximum of L. Downward gaze results in a significant increase in posterior eyewall concavity in highly myopic eyes after accounting for AL and staphyloma presence. In comparison with downward gaze, upgaze resulted in a lower magnitude, but significant changes in staphyloma ridge steepness and the likelihood of staphyloma presence. Horizontal gazes seemed to be associated with less posterior eyewall geometric parameters. Studies are required to further assess the association between downward gaze during near work on posterior eyewall concavity and possible effects on myopia development and progression.
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影响因子：
2.4
作者：
Grytz R;Girkin CA;Libertiaux V;Downs JC
通讯作者：
Downs JC
影响因子：
2.9
作者：
French, Amanda N.;Morgan, Ian G.;Rose, Kathryn A.
通讯作者：
Rose, Kathryn A.
影响因子：
1.4
作者：
Read, Scott A.;Collins, Michael J.;Cheong, Shiow-Huoy
通讯作者：
Cheong, Shiow-Huoy
影响因子：
13.7
作者：
Shinohara, Kosei;Tanaka, Noriko;Ohno-Matsui, Kyoko
通讯作者：
Ohno-Matsui, Kyoko
影响因子：
13.7
作者：
Holden, Brien A.;Fricke, Timothy R.;Resnikoff, Serge
通讯作者：
Resnikoff, Serge